Neuropsychiatric characteristics of GBA-associated Parkinson disease

Matthew Swan, Nancy Doan, Robert A. Ortega, Matthew Barrett, William Nichols, Laurie Ozelius, Jeannie Soto-Valencia, Sarah Boschung, Andres Deik, Harini Sarva, Jose Cabassa, Brooke Johannes, Deborah Raymond, Karen Marder, Nir Giladi, Joan Miravite, William Severt, Rivka Sachdev, Vicki Shanker, Susan Bressman & 1 others Rachel Saunders-Pullman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mutations in GBA1 are a well-established risk factor for Parkinson disease (PD). GBA-associated PD (GBA-PD) may have a higher burden of nonmotor symptoms than idiopathic PD (IPD). We sought to characterize the relationship between GBA-PD and neuropsychiatric symptoms. Subjects were screened for common GBA1 mutations. GBA-PD (n = 31) and non-carrier (IPD; n = 55) scores were compared on the Unified Parkinson Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), and the State-Trait Anxiety Index (STAI). In univariate comparisons, GBA-PD had a greater prevalence of depression (33.3%) versus IPD (13.2%) (p < 0.05). In regression models controlling for age, sex, disease duration, motor disability, and MoCA score, GBA-PD had an increased odds of depression (OR 3.66, 95% CI 1.13–11.8) (p = 0.03). Post-hoc analysis stratified by sex showed that, among men, GBA-PD had a higher burden of trait anxiety and depression than IPD; this finding was sustained in multivariate models. Among women, GBA-PD did not confer greater psychiatric morbidity than IPD. These results suggest that GBA1 mutations confer greater risk of neuropsychiatric morbidity in PD, and that sex may affect this association.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of the Neurological Sciences
Volume370
DOIs
StatePublished - Nov 15 2016

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Parkinson Disease
Depression
Mutation
Anxiety
Morbidity
Psychiatry
Equipment and Supplies

Keywords

  • Anxiety
  • Depression
  • GBA1
  • Glucocerebrosidase
  • Parkinson disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Swan, M., Doan, N., Ortega, R. A., Barrett, M., Nichols, W., Ozelius, L., ... Saunders-Pullman, R. (2016). Neuropsychiatric characteristics of GBA-associated Parkinson disease. Journal of the Neurological Sciences, 370, 63-69. https://doi.org/10.1016/j.jns.2016.08.059

Neuropsychiatric characteristics of GBA-associated Parkinson disease. / Swan, Matthew; Doan, Nancy; Ortega, Robert A.; Barrett, Matthew; Nichols, William; Ozelius, Laurie; Soto-Valencia, Jeannie; Boschung, Sarah; Deik, Andres; Sarva, Harini; Cabassa, Jose; Johannes, Brooke; Raymond, Deborah; Marder, Karen; Giladi, Nir; Miravite, Joan; Severt, William; Sachdev, Rivka; Shanker, Vicki; Bressman, Susan; Saunders-Pullman, Rachel.

In: Journal of the Neurological Sciences, Vol. 370, 15.11.2016, p. 63-69.

Research output: Contribution to journalArticle

Swan, M, Doan, N, Ortega, RA, Barrett, M, Nichols, W, Ozelius, L, Soto-Valencia, J, Boschung, S, Deik, A, Sarva, H, Cabassa, J, Johannes, B, Raymond, D, Marder, K, Giladi, N, Miravite, J, Severt, W, Sachdev, R, Shanker, V, Bressman, S & Saunders-Pullman, R 2016, 'Neuropsychiatric characteristics of GBA-associated Parkinson disease', Journal of the Neurological Sciences, vol. 370, pp. 63-69. https://doi.org/10.1016/j.jns.2016.08.059
Swan, Matthew ; Doan, Nancy ; Ortega, Robert A. ; Barrett, Matthew ; Nichols, William ; Ozelius, Laurie ; Soto-Valencia, Jeannie ; Boschung, Sarah ; Deik, Andres ; Sarva, Harini ; Cabassa, Jose ; Johannes, Brooke ; Raymond, Deborah ; Marder, Karen ; Giladi, Nir ; Miravite, Joan ; Severt, William ; Sachdev, Rivka ; Shanker, Vicki ; Bressman, Susan ; Saunders-Pullman, Rachel. / Neuropsychiatric characteristics of GBA-associated Parkinson disease. In: Journal of the Neurological Sciences. 2016 ; Vol. 370. pp. 63-69.
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abstract = "Mutations in GBA1 are a well-established risk factor for Parkinson disease (PD). GBA-associated PD (GBA-PD) may have a higher burden of nonmotor symptoms than idiopathic PD (IPD). We sought to characterize the relationship between GBA-PD and neuropsychiatric symptoms. Subjects were screened for common GBA1 mutations. GBA-PD (n = 31) and non-carrier (IPD; n = 55) scores were compared on the Unified Parkinson Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), and the State-Trait Anxiety Index (STAI). In univariate comparisons, GBA-PD had a greater prevalence of depression (33.3{\%}) versus IPD (13.2{\%}) (p < 0.05). In regression models controlling for age, sex, disease duration, motor disability, and MoCA score, GBA-PD had an increased odds of depression (OR 3.66, 95{\%} CI 1.13–11.8) (p = 0.03). Post-hoc analysis stratified by sex showed that, among men, GBA-PD had a higher burden of trait anxiety and depression than IPD; this finding was sustained in multivariate models. Among women, GBA-PD did not confer greater psychiatric morbidity than IPD. These results suggest that GBA1 mutations confer greater risk of neuropsychiatric morbidity in PD, and that sex may affect this association.",
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AU - Miravite, Joan

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