Neuroprotective effects of quercetin in alzheimer’s disease

Haroon Khan, Hammad Ullah, Michael Aschner, Wai San Cheang, Esra Küpeli Akkol

Research output: Contribution to journalReview article

Abstract

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

Original languageEnglish (US)
Article number59
JournalBiomolecules
Volume10
Issue number1
DOIs
StatePublished - Jan 2020

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Quercetin
Neuroprotective Agents
Alzheimer Disease
Lead compounds
Amyloidogenic Proteins
Vegetables
Therapeutic Uses
Nutrition
Fruits
Flavonoids
Lipid Peroxidation
Neurons
Fruit
Antioxidants
Pharmacology
Diet
Lipids

Keywords

  • Alzheimer’s disease
  • Clinical directions
  • Mechanistic insights
  • Polyphenols
  • Quercetin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Neuroprotective effects of quercetin in alzheimer’s disease. / Khan, Haroon; Ullah, Hammad; Aschner, Michael; Cheang, Wai San; Akkol, Esra Küpeli.

In: Biomolecules, Vol. 10, No. 1, 59, 01.2020.

Research output: Contribution to journalReview article

Khan, Haroon ; Ullah, Hammad ; Aschner, Michael ; Cheang, Wai San ; Akkol, Esra Küpeli. / Neuroprotective effects of quercetin in alzheimer’s disease. In: Biomolecules. 2020 ; Vol. 10, No. 1.
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