Neuroprotective effects of quercetin in alzheimer’s disease

Haroon Khan; Hammad Ullah; Michael Aschner; Wai San Cheang; Esra Küpeli Akkol

doi:10.3390/biom10010059

Neuroprotective effects of quercetin in alzheimer’s disease

Haroon Khan, Hammad Ullah, Michael Aschner, Wai San Cheang, Esra Küpeli Akkol

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

267 Scopus citations

Abstract

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

Original language	English (US)
Article number	59
Journal	Biomolecules
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/biom10010059
State	Published - Jan 2020

Keywords

Alzheimer’s disease
Clinical directions
Mechanistic insights
Polyphenols
Quercetin

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.3390/biom10010059

Cite this

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abstract = "Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer{\textquoteright}s disease and its potential as a lead compound in clinical applications.",

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AU - Khan, Haroon

AU - Ullah, Hammad

AU - Aschner, Michael

AU - Cheang, Wai San

AU - Akkol, Esra Küpeli

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N2 - Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

AB - Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

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KW - Clinical directions

KW - Mechanistic insights

KW - Polyphenols

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Neuroprotective effects of quercetin in alzheimer’s disease

Abstract

Keywords

ASJC Scopus subject areas

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