Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density

Inmaculada Tasset, F. J. Medina, I. Jimena, E. Agüera, F. Gascón, M. Feijóo, F. Sánchez-López, E. Luque, J. Peña, R. Drucker-Colín, I. Túnez

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.

Original languageEnglish (US)
Pages (from-to)54-63
Number of pages10
JournalNeuroscience
Volume209
DOIs
StatePublished - May 3 2012
Externally publishedYes

Fingerprint

Electromagnetic Fields
Huntington Disease
Nerve Growth Factors
Neuroprotective Agents
Oxidative Stress
Biomarkers
Brain Injuries
3-nitropropionic acid
Wistar Rats
Cell Survival
Body Weight
Neurons
Injections

Keywords

  • Behavior
  • Cell damage
  • Extremely low-frequency electromagnetic fields
  • Neuroplasticity
  • Neuroprotective
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model : Effects on neurotrophic factors and neuronal density. / Tasset, Inmaculada; Medina, F. J.; Jimena, I.; Agüera, E.; Gascón, F.; Feijóo, M.; Sánchez-López, F.; Luque, E.; Peña, J.; Drucker-Colín, R.; Túnez, I.

In: Neuroscience, Vol. 209, 03.05.2012, p. 54-63.

Research output: Contribution to journalArticle

Tasset, I, Medina, FJ, Jimena, I, Agüera, E, Gascón, F, Feijóo, M, Sánchez-López, F, Luque, E, Peña, J, Drucker-Colín, R & Túnez, I 2012, 'Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density', Neuroscience, vol. 209, pp. 54-63. https://doi.org/10.1016/j.neuroscience.2012.02.034
Tasset, Inmaculada ; Medina, F. J. ; Jimena, I. ; Agüera, E. ; Gascón, F. ; Feijóo, M. ; Sánchez-López, F. ; Luque, E. ; Peña, J. ; Drucker-Colín, R. ; Túnez, I. / Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model : Effects on neurotrophic factors and neuronal density. In: Neuroscience. 2012 ; Vol. 209. pp. 54-63.
@article{595ce8d7b7c947139a36b713ce2bd83f,
title = "Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density",
abstract = "There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.",
keywords = "Behavior, Cell damage, Extremely low-frequency electromagnetic fields, Neuroplasticity, Neuroprotective, Oxidative stress",
author = "Inmaculada Tasset and Medina, {F. J.} and I. Jimena and E. Ag{\"u}era and F. Gasc{\'o}n and M. Feij{\'o}o and F. S{\'a}nchez-L{\'o}pez and E. Luque and J. Pe{\~n}a and R. Drucker-Col{\'i}n and I. T{\'u}nez",
year = "2012",
month = "5",
day = "3",
doi = "10.1016/j.neuroscience.2012.02.034",
language = "English (US)",
volume = "209",
pages = "54--63",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model

T2 - Effects on neurotrophic factors and neuronal density

AU - Tasset, Inmaculada

AU - Medina, F. J.

AU - Jimena, I.

AU - Agüera, E.

AU - Gascón, F.

AU - Feijóo, M.

AU - Sánchez-López, F.

AU - Luque, E.

AU - Peña, J.

AU - Drucker-Colín, R.

AU - Túnez, I.

PY - 2012/5/3

Y1 - 2012/5/3

N2 - There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.

AB - There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.

KW - Behavior

KW - Cell damage

KW - Extremely low-frequency electromagnetic fields

KW - Neuroplasticity

KW - Neuroprotective

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84859268378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859268378&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2012.02.034

DO - 10.1016/j.neuroscience.2012.02.034

M3 - Article

C2 - 22406415

AN - SCOPUS:84859268378

VL - 209

SP - 54

EP - 63

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -