Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density

I. Tasset, F. J. Medina, I. Jimena, E. Agüera, F. Gascón, M. Feijóo, F. Sánchez-López, E. Luque, J. Peña, R. Drucker-Colín, I. Túnez

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

There is evidence to suggest that the neuroprotective effect of exposure of extremely low-frequency electromagnetic fields (ELF-EMF) may be due, at least in part, to the effect of these fields on neurotrophic factors levels and cell survival, leading to an improvement in behavior. This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease. Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative stress biomarker levels were monitored in Wistar rats. Rats were given 3NP over four consecutive days (20 mg/kg body weight), whereas ELFEF (60 Hz and 0.7 mT) was applied over 21 days, starting after the last injection of 3NP. Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and the forced swim test (FST), and displayed significant differences in neurotrophic factor levels and oxidative stress biomarkers levels, together with a neuronal damage and diminished neuronal density, with respect neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats. ELFEF alleviates 3NP-induced brain injury and prevents loss of neurons in rat striatum, thus showing considerable potential as a therapeutic tool.

Original languageEnglish (US)
Pages (from-to)54-63
Number of pages10
JournalNeuroscience
Volume209
DOIs
StatePublished - May 3 2012
Externally publishedYes

Keywords

  • Behavior
  • Cell damage
  • Extremely low-frequency electromagnetic fields
  • Neuroplasticity
  • Neuroprotective
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density'. Together they form a unique fingerprint.

  • Cite this

    Tasset, I., Medina, F. J., Jimena, I., Agüera, E., Gascón, F., Feijóo, M., Sánchez-López, F., Luque, E., Peña, J., Drucker-Colín, R., & Túnez, I. (2012). Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: Effects on neurotrophic factors and neuronal density. Neuroscience, 209, 54-63. https://doi.org/10.1016/j.neuroscience.2012.02.034