Abstract
Background: Atypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood. Methods: We sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6–17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132). Results: Statistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain. Conclusions: These results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism.
Original language | English (US) |
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Article number | 11 |
Journal | Journal of Neurodevelopmental Disorders |
Volume | 15 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2023 |
Keywords
- Adaptive behavior
- Auditory processing
- Autism Spectrum Disorder
- Electroencephalography
- Event related potentials
- Lateralization
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pathology and Forensic Medicine
- Clinical Neurology
- Cognitive Neuroscience