Abstract
Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and (1) autism severity and (2) sensory sensitivities, in individuals with ASD aged 6–17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 230-244 |
| Number of pages | 15 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
Fingerprint
Keywords
- ADOS
- ASD
- Electrophysiology
- ERP
- Multisensory integration
- Sensory Profile
ASJC Scopus subject areas
- Developmental and Educational Psychology
Cite this
Neurophysiological Indices of Atypical Auditory Processing and Multisensory Integration are Associated with Symptom Severity in Autism. / Brandwein, Alice B.; Foxe, John J.; Butler, John S.; Frey, Hans Peter; Bates, Juliana C.; Shulman, Lisa H.; Molholm, Sophie.
In: Journal of Autism and Developmental Disorders, Vol. 45, No. 1, 2014, p. 230-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurophysiological Indices of Atypical Auditory Processing and Multisensory Integration are Associated with Symptom Severity in Autism
AU - Brandwein, Alice B.
AU - Foxe, John J.
AU - Butler, John S.
AU - Frey, Hans Peter
AU - Bates, Juliana C.
AU - Shulman, Lisa H.
AU - Molholm, Sophie
PY - 2014
Y1 - 2014
N2 - Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and (1) autism severity and (2) sensory sensitivities, in individuals with ASD aged 6–17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
AB - Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and (1) autism severity and (2) sensory sensitivities, in individuals with ASD aged 6–17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
KW - ADOS
KW - ASD
KW - Electrophysiology
KW - ERP
KW - Multisensory integration
KW - Sensory Profile
UR - http://www.scopus.com/inward/record.url?scp=84922076766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922076766&partnerID=8YFLogxK
U2 - 10.1007/s10803-014-2212-9
DO - 10.1007/s10803-014-2212-9
M3 - Article
C2 - 25245785
AN - SCOPUS:84922076766
VL - 45
SP - 230
EP - 244
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 1
ER -