Abstract
We report a method to identify neuropeptides in specific cell types, using mice with a conditional deletion of carboxypeptidase E. It was validated by deleting CPE in proopiomelanocortin cells. Surprisingly, these mice have greatly reduced levels of the anorexigenic peptide α-MSH but are not obese.
Original language | English (US) |
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Pages (from-to) | 105-112.e4 |
Journal | Cell Chemical Biology |
Volume | 28 |
Issue number | 1 |
DOIs | |
State | Published - Jan 21 2021 |
Keywords
- Proteomics
- carboxypeptidase
- neuropeptide
- neuropeptidomics
- peptidomics
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry