Neuropeptide biosynthesis

focus on the carboxypeptidase processing enzyme

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Many peptide neurotransmitters and hormones are initially synthesized as large protein precursors (prohormones) which must undergo proteolytic processing to yield the biologically active fragment. Often, the neurotransmitter or hormone is flanked by pairs of basic amino acids in the precursor molecule, and the sequential action of a trypsin-like endopeptidase followed by a carboxypeptidase-B-like exopeptidase would liberate the hormone. An important question is whether unique enzymes are associated with each prohormone, or whether general processing enzymes perform similar cleavages for all prohormones. Recent studies on the carboxypeptidase-B-like processing enzyme associated with enkephalin biosynthesis suggests that this enzyme is also involved in the biosynthesis of many other peptide hormones and neurotransmitters.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalTrends in Neurosciences
Volume8
Issue numberC
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Carboxypeptidases
Neuropeptides
Carboxypeptidase B
Neurotransmitter Agents
Peptide Hormones
Enzymes
Exopeptidases
Hormones
Basic Amino Acids
Endopeptidases
Protein Precursors
Enkephalins
Trypsin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuropeptide biosynthesis : focus on the carboxypeptidase processing enzyme. / Fricker, Lloyd D.

In: Trends in Neurosciences, Vol. 8, No. C, 1985, p. 210-214.

Research output: Contribution to journalArticle

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