Neuropathological perspective on single slide

Asao Hirano

Research output: Contribution to journalArticle

Abstract

During over 50 years of my career in Neuropathology at Montefiore Medical Center in New York, I have come across certain interesting neuropathological findings. In this communication, some photographs showing macroscopic, microscopic and electron microscopic significant findings are selected to illustrate the usefulness, not only for the diagnosis but also for the understanding of the nervous system. The 11 topics presented in this paper are: (1) alteration of dura mater associated with advanced aging; (2) orderly arrangement of tumor cells in leptomeningeal carcinomatosis; (3) horizontal section of brain with border zone infarct; (4) neurofibrillary tangle formation in the nucleus basalis Meynert ipsilateral to a massive cerebral infarct; (5) extracellular spread of hematogenous edema fluid in the white matter; (6) unrolled myelin sheath; (7) unattached presynaptic terminals in cerebellar neuroblastoma; (8) unattached post synaptic terminals in agranular cerebellar degeneration; (9) neurofibrillary tangles and Lewy bodes in a single neuron; (10) Cu/Zu superoxide dismutase positive Lewy body-like hyaline inclusions in anterior horn cells in familial motor neuron disease; (11) Hirano body. Analysis of these findings are presented for an educational purpose.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
JournalClinical Neurology
Volume48
Issue number11
StatePublished - Nov 2008

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Neurofibrillary Tangles
Presynaptic Terminals
Meningeal Carcinomatosis
Basal Nucleus of Meynert
Anterior Horn Cells
Lewy Bodies
Dura Mater
Motor Neuron Disease
Hyalin
Myelin Sheath
Neuroblastoma
Nervous System
Superoxide Dismutase
Edema
Electrons
Neurons
Brain
Neoplasms
Neuropathology
White Matter

Keywords

  • Brain edema
  • Hirano body
  • Lewy body-like inclusion
  • Myelin
  • Synapse

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neuropathological perspective on single slide. / Hirano, Asao.

In: Clinical Neurology, Vol. 48, No. 11, 11.2008, p. 804-808.

Research output: Contribution to journalArticle

Hirano, A 2008, 'Neuropathological perspective on single slide', Clinical Neurology, vol. 48, no. 11, pp. 804-808.
Hirano, Asao. / Neuropathological perspective on single slide. In: Clinical Neurology. 2008 ; Vol. 48, No. 11. pp. 804-808.
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