Neuronal nitric oxide synthase expression in developing and adult human CNS

Martha Downen, Meng Liang Zhao, Paul Lee, Karen M. Weidenheim, Dennis W. Dickson, Sunhee C. Lee

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Neuronal nitric oxide synthase (nNOS) is constitutively expressed by subpopulations of neurons in the CNS and is involved in neurotransmission, learning and memory, and neuronal injury. While the distribution of nNOS neurons has been characterized in the rodent CNS, the expression in human brain has not been well documented. We determined the expression of nNOS in second trimester human fetal and adult brain. In second trimester fetal brain, the nNOS neurons are concentrated in the developing cerebral cortex at the subplate zone and in layer VI, the striatum, and in certain brainstem nuclei. The nNOS neurons are sparsely distributed in the hippocampus, and virtually absent in the cerebellar cortex. The nNOS neurons in the subplate zone extend their processes radially, suggesting a developmental role, perhaps in guidance. The number and distribution of NADPH diaphorase-positive neurons corresponds to that of the nNOS neurons. While the distribution of nNOS neurons in the adult brain is similar to that found in fetal brain, the overall density is lower in the adult. The highest density' of nNOS neurons is found in the striatum followed by the neocortex. A region-specific role for nNOS neurons in human brain and a potential developmental role for nNOS in the cerebral cortex are suggested by these data.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume58
Issue number1
StatePublished - Jan 1999

Fingerprint

Nitric Oxide Synthase Type I
Neurons
Brain
Second Pregnancy Trimester
Cerebral Cortex
NADPH Dehydrogenase
Cerebellar Cortex
Neocortex
Synaptic Transmission
Brain Stem
Rodentia
Hippocampus
Learning

Keywords

  • Adult
  • CNS
  • Fetal
  • Human
  • NADPH diaphorase
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Downen, M., Zhao, M. L., Lee, P., Weidenheim, K. M., Dickson, D. W., & Lee, S. C. (1999). Neuronal nitric oxide synthase expression in developing and adult human CNS. Journal of Neuropathology and Experimental Neurology, 58(1), 12-21.

Neuronal nitric oxide synthase expression in developing and adult human CNS. / Downen, Martha; Zhao, Meng Liang; Lee, Paul; Weidenheim, Karen M.; Dickson, Dennis W.; Lee, Sunhee C.

In: Journal of Neuropathology and Experimental Neurology, Vol. 58, No. 1, 01.1999, p. 12-21.

Research output: Contribution to journalArticle

Downen, M, Zhao, ML, Lee, P, Weidenheim, KM, Dickson, DW & Lee, SC 1999, 'Neuronal nitric oxide synthase expression in developing and adult human CNS', Journal of Neuropathology and Experimental Neurology, vol. 58, no. 1, pp. 12-21.
Downen M, Zhao ML, Lee P, Weidenheim KM, Dickson DW, Lee SC. Neuronal nitric oxide synthase expression in developing and adult human CNS. Journal of Neuropathology and Experimental Neurology. 1999 Jan;58(1):12-21.
Downen, Martha ; Zhao, Meng Liang ; Lee, Paul ; Weidenheim, Karen M. ; Dickson, Dennis W. ; Lee, Sunhee C. / Neuronal nitric oxide synthase expression in developing and adult human CNS. In: Journal of Neuropathology and Experimental Neurology. 1999 ; Vol. 58, No. 1. pp. 12-21.
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