Neuromuscular blockers

Gabriel Goodwin, Vilma A. Joseph

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Muscle relaxants were first used on poisonous darts by South American Indians during hunting, according to accounts found in the court of King Ferdinand and Queen Isabella. It took several hundred years until their therapeutic potential was realized in the medical setting. Tubocurarine, the first muscle relaxant used clinically, often produced hypotension and tachycardia through histamine release. Today, we have sophisticated neuromuscular blockers (NMBs) that keep the patient paralyzed providing ideal surgical conditions, facilitating intubation and artificial ventilation, with minimal changes to vital signs.

Original languageEnglish (US)
Title of host publicationEssentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care
PublisherSpringer New York
Number of pages10
ISBN (Print)9781461489481, 9781461489474
Publication statusPublished - Jan 1 2015


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Goodwin, G., & Joseph, V. A. (2015). Neuromuscular blockers. In Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care (pp. 195-204). Springer New York.