Neurological soft signs as predictors of treatment response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder

Eric Hollander, Alicia Kaplan, James Schmeidler, Haichen Yang, David Li, Lorrin M. Koran, Luigi M. Barbato

Research output: Contribution to journalArticle

36 Scopus citations


Neurological soft-sign abnormalities have been implicated in obsessive-compulsive disorder (OCD). This first comprehensive data analysis evaluated the association between baseline neurological soft signs and treatment response in 117 OCD patients treated with controlled-release fluvoxamine in a double-blind placebo-controlled trial. Total and right-sided soft signs for the responders and the nonresponders did not differ significantly. Left-sided visuospatial soft signs were significantly increased in treatment nonresponders compared to responders. These subtle neurological abnormalities may implicate a potential subgroup of OCD patients with poorer treatment response. This may have treatment implications and therefore serve as a screening tool in OCD.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 2005


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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