Neurological complications in infants and children with acquired immune deficiency syndrome

A. L. Belman, M. H. Ultmann, D. Horoupian, B. Novick, A. J. Spiro, Arye Rubinstein, D. Kurtzberg, B. Cone-Wesson

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Neurological complications occurred in 6 children, aged 6 months to 5 years, with acquired immune deficiency syndrome who were followed for 14 months. The most frequent manifestations included encephalopathies, acquired microcephaly, and pyramidal tract signs. Computed tomographic examinations showed variable degrees of cortical atrophy with ventricular dilatation and calcification. Electrophysiological abnormalities were demonstrated. Two children had documented central nervous system infections. Neurological deterioration resulted in dementia in 3 children. Cognitive impairment and developmental delays were evident in the other 3. Postmortem examination of the 3 children who died showed subacute cytomegalovirus encephalitis in 1; nonspecific hemispheric white matter changes, calcific vasopathy of the basal ganglia, and striking bilateral corticospinal tract degeneration in the second; and extensive calcific vasopathy of the basal ganglia and frontal centrum semiovale, and bilateral attenuation of the frontopontine and corticospinal tracts in the third.

Original languageEnglish (US)
Pages (from-to)560-566
Number of pages7
JournalAnnals of Neurology
Volume18
Issue number5
DOIs
StatePublished - 1985

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Pyramidal Tracts
Acquired Immunodeficiency Syndrome
Basal Ganglia
Central Nervous System Infections
Microcephaly
Brain Diseases
Encephalitis
Cytomegalovirus
Atrophy
Dementia
Dilatation
Autopsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Belman, A. L., Ultmann, M. H., Horoupian, D., Novick, B., Spiro, A. J., Rubinstein, A., ... Cone-Wesson, B. (1985). Neurological complications in infants and children with acquired immune deficiency syndrome. Annals of Neurology, 18(5), 560-566. https://doi.org/10.1002/ana.410180509

Neurological complications in infants and children with acquired immune deficiency syndrome. / Belman, A. L.; Ultmann, M. H.; Horoupian, D.; Novick, B.; Spiro, A. J.; Rubinstein, Arye; Kurtzberg, D.; Cone-Wesson, B.

In: Annals of Neurology, Vol. 18, No. 5, 1985, p. 560-566.

Research output: Contribution to journalArticle

Belman, AL, Ultmann, MH, Horoupian, D, Novick, B, Spiro, AJ, Rubinstein, A, Kurtzberg, D & Cone-Wesson, B 1985, 'Neurological complications in infants and children with acquired immune deficiency syndrome', Annals of Neurology, vol. 18, no. 5, pp. 560-566. https://doi.org/10.1002/ana.410180509
Belman, A. L. ; Ultmann, M. H. ; Horoupian, D. ; Novick, B. ; Spiro, A. J. ; Rubinstein, Arye ; Kurtzberg, D. ; Cone-Wesson, B. / Neurological complications in infants and children with acquired immune deficiency syndrome. In: Annals of Neurology. 1985 ; Vol. 18, No. 5. pp. 560-566.
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AU - Ultmann, M. H.

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AU - Rubinstein, Arye

AU - Kurtzberg, D.

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