Neuroinflammatory and autonomic mechanisms in diabetes and hypertension

Cheng Han, Mattheww Rice, Dongsheng Cai

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Interdisciplinary studies in the research fields of endocrinology and immunology show that obesityassociated overnutrition leads to neuroinflammatory molecular changes, in particular in the hypothalamus, chronically causing various disorders known as elements of metabolic syndrome. In this process, neural or hypothalamic inflammation impairs the neuroendocrine and autonomic regulation of the brain over blood pressure and glucose homeostasis as well as insulin secretion, and elevated sympathetic activation has been appreciated as a critical mediator. This review describes the involved physiology and mechanisms, with a focus on glucose and blood pressure balance, and suggests that neuroinflammation employs the autonomic nervous system to mediate the development of diabetes and hypertension.

Original languageEnglish (US)
Pages (from-to)E32-E41
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume311
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Interdisciplinary Studies
Overnutrition
Blood Pressure
Hypertension
Endocrinology
Autonomic Nervous System
Allergy and Immunology
Hypothalamus
Blood Glucose
Homeostasis
Insulin
Inflammation
Glucose
Brain
Research

Keywords

  • Autonomic nervous system
  • Hypothalamus
  • Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Medicine(all)
  • Physiology (medical)

Cite this

Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. / Han, Cheng; Rice, Mattheww; Cai, Dongsheng.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 311, No. 1, 01.07.2016, p. E32-E41.

Research output: Contribution to journalReview article

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