Neuroinflammation in the pathogenesis of early life epileptic encephalopathies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.

Original languageEnglish (US)
Title of host publicationAcute Encephalopathy and Encephalitis in Infancy and Its Related Disorders
PublisherElsevier Inc.
Pages33-44
Number of pages12
ISBN (Electronic)9780323530903
ISBN (Print)9780323530880
DOIs
StatePublished - Nov 2 2017

Fingerprint

Infantile Spasms
Brain Diseases
Landau-Kleffner Syndrome
Myoclonic Epilepsy
Sleep
Therapeutics
Cognitive Dysfunction
Lennox Gastaut Syndrome
Clinical Studies

Keywords

  • ACTH
  • Cognition
  • Cytokines
  • Dysplasia
  • Infantile spasms
  • Interleukin
  • MTOR
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Salar, S., & Galanopoulou, A. S. (2017). Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. In Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders (pp. 33-44). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-53088-0.00005-1

Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. / Salar, Seda; Galanopoulou, Aristea S.

Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders. Elsevier Inc., 2017. p. 33-44.

Research output: Chapter in Book/Report/Conference proceedingChapter

Salar, S & Galanopoulou, AS 2017, Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. in Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders. Elsevier Inc., pp. 33-44. https://doi.org/10.1016/B978-0-323-53088-0.00005-1
Salar S, Galanopoulou AS. Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. In Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders. Elsevier Inc. 2017. p. 33-44 https://doi.org/10.1016/B978-0-323-53088-0.00005-1
Salar, Seda ; Galanopoulou, Aristea S. / Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders. Elsevier Inc., 2017. pp. 33-44
@inbook{831dc1ec198444ec84ef2b32b05b0117,
title = "Neuroinflammation in the pathogenesis of early life epileptic encephalopathies",
abstract = "Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.",
keywords = "ACTH, Cognition, Cytokines, Dysplasia, Infantile spasms, Interleukin, MTOR, Treatment",
author = "Seda Salar and Galanopoulou, {Aristea S.}",
year = "2017",
month = "11",
day = "2",
doi = "10.1016/B978-0-323-53088-0.00005-1",
language = "English (US)",
isbn = "9780323530880",
pages = "33--44",
booktitle = "Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Neuroinflammation in the pathogenesis of early life epileptic encephalopathies

AU - Salar, Seda

AU - Galanopoulou, Aristea S.

PY - 2017/11/2

Y1 - 2017/11/2

N2 - Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.

AB - Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.

KW - ACTH

KW - Cognition

KW - Cytokines

KW - Dysplasia

KW - Infantile spasms

KW - Interleukin

KW - MTOR

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85054461212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054461212&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-53088-0.00005-1

DO - 10.1016/B978-0-323-53088-0.00005-1

M3 - Chapter

AN - SCOPUS:85054461212

SN - 9780323530880

SP - 33

EP - 44

BT - Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders

PB - Elsevier Inc.

ER -