Neuroinflammation in the pathogenesis of early life epileptic encephalopathies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epileptic encephalopathies consist of a spectrum of disorders commonly seen early in life leading to cognitive impairment and behavioral abnormalities, thought to be largely due to the intense epileptic activity. To date, genetic, structural/metabolic, inflammatory, and functional/network changes are identified as underlying etiologies of these disorders. Here we will focus on the role of neuroinflammation as a potential contributor to the pathogenesis and treatment of some of these disorders, based on clinical and preclinical studies. Namely, we will focus on infantile spasms/West syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, continuous spike waves in sleep syndrome, and Dravet syndrome.

Original languageEnglish (US)
Title of host publicationAcute Encephalopathy and Encephalitis in Infancy and Its Related Disorders
PublisherElsevier Inc.
Pages33-44
Number of pages12
ISBN (Electronic)9780323530903
ISBN (Print)9780323530880
DOIs
StatePublished - Jan 1 2018

Keywords

  • ACTH
  • Cognition
  • Cytokines
  • Dysplasia
  • Infantile spasms
  • Interleukin
  • MTOR
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Salar, S., & Galanopoulou, A. S. (2018). Neuroinflammation in the pathogenesis of early life epileptic encephalopathies. In Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders (pp. 33-44). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-53088-0.00005-1