Neuroinflammation in Overnutrition-Induced Diseases

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Inflammation is a biological response mounted by the immune system against dangerous assaults that threaten the integrity and normal physiology of an organism. During the past decades, cross-disciplinary research from immunology and endocrinology has much broadened this knowledge by demonstrating that chronic conditions of nutritional excess constitute an independent category of inflammatory activators, and the resulting chronic and low-grade inflammation is an important characteristic of overnutrition-induced diseases. A large body of research has demonstrated that these diseases are pathogenically associated with the local, negative actions of inflammation in peripheral tissues predominantly including the liver, muscle, and fat. In this research background, more recent research has advanced to a new level, with the important discoveries showing that overnutrition-induced inflammation occurs in the brain and thus plays a broad and leadership role in overnutrition-induced diseases. While much more research establishments are expected in this emerging and quickly expanding research, the appreciated understandings have been mainly based on proinflammatory IKKβ/NF-κB pathway and related molecules in the hypothalamus. In this chapter, the author focuses on describing IKKβ/NF-κB-induced neural inflammation in the context of overnutrition-induced metabolic inflammation and especially the central roles of this neural inflammation in the development of a spectrum of overnutrition-related diseases.

Original languageEnglish (US)
Pages (from-to)195-218
Number of pages24
JournalVitamins and Hormones
Volume91
DOIs
StatePublished - 2013

Fingerprint

Overnutrition
Inflammation
Research
Endocrinology
Allergy and Immunology
Hypothalamus
Immune System
Fats
Muscles
Liver
Brain

Keywords

  • Body weight
  • Cardiovascular diseases
  • Central nervous system
  • Diabetes
  • Energy balance
  • Feeding
  • Glucose tolerance
  • Hypertension
  • Hypothalamus
  • IKKβ
  • Inflammation
  • Insulin resistance
  • Metabolism
  • Neural stem cell
  • Neurodegeneration
  • NF-κB
  • Obesity
  • Overnutrition
  • Stroke

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Neuroinflammation in Overnutrition-Induced Diseases. / Cai, Dongsheng.

In: Vitamins and Hormones, Vol. 91, 2013, p. 195-218.

Research output: Contribution to journalArticle

@article{e0fe7c8619104884af2e6f77843f94a7,
title = "Neuroinflammation in Overnutrition-Induced Diseases",
abstract = "Inflammation is a biological response mounted by the immune system against dangerous assaults that threaten the integrity and normal physiology of an organism. During the past decades, cross-disciplinary research from immunology and endocrinology has much broadened this knowledge by demonstrating that chronic conditions of nutritional excess constitute an independent category of inflammatory activators, and the resulting chronic and low-grade inflammation is an important characteristic of overnutrition-induced diseases. A large body of research has demonstrated that these diseases are pathogenically associated with the local, negative actions of inflammation in peripheral tissues predominantly including the liver, muscle, and fat. In this research background, more recent research has advanced to a new level, with the important discoveries showing that overnutrition-induced inflammation occurs in the brain and thus plays a broad and leadership role in overnutrition-induced diseases. While much more research establishments are expected in this emerging and quickly expanding research, the appreciated understandings have been mainly based on proinflammatory IKKβ/NF-κB pathway and related molecules in the hypothalamus. In this chapter, the author focuses on describing IKKβ/NF-κB-induced neural inflammation in the context of overnutrition-induced metabolic inflammation and especially the central roles of this neural inflammation in the development of a spectrum of overnutrition-related diseases.",
keywords = "Body weight, Cardiovascular diseases, Central nervous system, Diabetes, Energy balance, Feeding, Glucose tolerance, Hypertension, Hypothalamus, IKKβ, Inflammation, Insulin resistance, Metabolism, Neural stem cell, Neurodegeneration, NF-κB, Obesity, Overnutrition, Stroke",
author = "Dongsheng Cai",
year = "2013",
doi = "10.1016/B978-0-12-407766-9.00008-0",
language = "English (US)",
volume = "91",
pages = "195--218",
journal = "Vitamins and Hormones",
issn = "0083-6729",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Neuroinflammation in Overnutrition-Induced Diseases

AU - Cai, Dongsheng

PY - 2013

Y1 - 2013

N2 - Inflammation is a biological response mounted by the immune system against dangerous assaults that threaten the integrity and normal physiology of an organism. During the past decades, cross-disciplinary research from immunology and endocrinology has much broadened this knowledge by demonstrating that chronic conditions of nutritional excess constitute an independent category of inflammatory activators, and the resulting chronic and low-grade inflammation is an important characteristic of overnutrition-induced diseases. A large body of research has demonstrated that these diseases are pathogenically associated with the local, negative actions of inflammation in peripheral tissues predominantly including the liver, muscle, and fat. In this research background, more recent research has advanced to a new level, with the important discoveries showing that overnutrition-induced inflammation occurs in the brain and thus plays a broad and leadership role in overnutrition-induced diseases. While much more research establishments are expected in this emerging and quickly expanding research, the appreciated understandings have been mainly based on proinflammatory IKKβ/NF-κB pathway and related molecules in the hypothalamus. In this chapter, the author focuses on describing IKKβ/NF-κB-induced neural inflammation in the context of overnutrition-induced metabolic inflammation and especially the central roles of this neural inflammation in the development of a spectrum of overnutrition-related diseases.

AB - Inflammation is a biological response mounted by the immune system against dangerous assaults that threaten the integrity and normal physiology of an organism. During the past decades, cross-disciplinary research from immunology and endocrinology has much broadened this knowledge by demonstrating that chronic conditions of nutritional excess constitute an independent category of inflammatory activators, and the resulting chronic and low-grade inflammation is an important characteristic of overnutrition-induced diseases. A large body of research has demonstrated that these diseases are pathogenically associated with the local, negative actions of inflammation in peripheral tissues predominantly including the liver, muscle, and fat. In this research background, more recent research has advanced to a new level, with the important discoveries showing that overnutrition-induced inflammation occurs in the brain and thus plays a broad and leadership role in overnutrition-induced diseases. While much more research establishments are expected in this emerging and quickly expanding research, the appreciated understandings have been mainly based on proinflammatory IKKβ/NF-κB pathway and related molecules in the hypothalamus. In this chapter, the author focuses on describing IKKβ/NF-κB-induced neural inflammation in the context of overnutrition-induced metabolic inflammation and especially the central roles of this neural inflammation in the development of a spectrum of overnutrition-related diseases.

KW - Body weight

KW - Cardiovascular diseases

KW - Central nervous system

KW - Diabetes

KW - Energy balance

KW - Feeding

KW - Glucose tolerance

KW - Hypertension

KW - Hypothalamus

KW - IKKβ

KW - Inflammation

KW - Insulin resistance

KW - Metabolism

KW - Neural stem cell

KW - Neurodegeneration

KW - NF-κB

KW - Obesity

KW - Overnutrition

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=84873802447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873802447&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-407766-9.00008-0

DO - 10.1016/B978-0-12-407766-9.00008-0

M3 - Article

VL - 91

SP - 195

EP - 218

JO - Vitamins and Hormones

JF - Vitamins and Hormones

SN - 0083-6729

ER -