Neuroimaging in Blast-Related Mild Traumatic Brain Injury

Weiya Mu, Eva Catenaccio, Michael L. Lipton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE:: To summarize imaging findings in blast-related mild traumatic brain injury. DESIGN:: Our structured review of the literature yielded 5 structural magnetic resonance imaging (sMRI), 18 diffusion tensor imaging, 9 functional magnetic resonance imaging (fMRI), 3 positron emission tomography, 4 magnetoencephalography, 2 electroencephalography, and 1 single-positron emission computerized tomography studies. RESULTS:: Four of the 5 sMRI studies reported decreased cortical thickness and decreased thalamus and amygdala volume. Diffusion tensor imaging studies showed abnormal diffusion within white matter tracts commonly associated with traumatic brain injury, including the corpus callosum (8 of the 18) and superior longitudinal fasciculus (8 of the 18). Resting-state fMRI studies reported a variety of functional network differences. Other functional imaging studies showed diffuse changes in activity, especially in the frontal, parietal, temporal, and cingulate regions. CONCLUSION:: Vast variation in the sample, design, and measurement features across studies precludes salient conclusions regarding the effectiveness of neuroimaging to assess outcomes and elucidate pathomechanisms. The inherent spatial heterogeneity of mild traumatic brain injury pathology presents a major challenge to meaningful convergence across and generalizable inferences. Approaches to standardize methodology and facilitate access to data and integration across studies hold promise for enhancing our understanding of this complex brain disorder, but can only bear fruit if they are actually consistently implemented.

Original languageEnglish (US)
JournalJournal of Head Trauma Rehabilitation
DOIs
StateAccepted/In press - Mar 28 2016

Fingerprint

Brain Concussion
Neuroimaging
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Positron-Emission Tomography
Magnetoencephalography
Parietal Lobe
Corpus Callosum
Gyrus Cinguli
Brain Diseases
Temporal Lobe
Amygdala
Thalamus
Electroencephalography
Fruit
Pathology

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Neuroimaging in Blast-Related Mild Traumatic Brain Injury. / Mu, Weiya; Catenaccio, Eva; Lipton, Michael L.

In: Journal of Head Trauma Rehabilitation, 28.03.2016.

Research output: Contribution to journalArticle

@article{bb3aa9c994494a35b94dbbfa18956285,
title = "Neuroimaging in Blast-Related Mild Traumatic Brain Injury",
abstract = "OBJECTIVE:: To summarize imaging findings in blast-related mild traumatic brain injury. DESIGN:: Our structured review of the literature yielded 5 structural magnetic resonance imaging (sMRI), 18 diffusion tensor imaging, 9 functional magnetic resonance imaging (fMRI), 3 positron emission tomography, 4 magnetoencephalography, 2 electroencephalography, and 1 single-positron emission computerized tomography studies. RESULTS:: Four of the 5 sMRI studies reported decreased cortical thickness and decreased thalamus and amygdala volume. Diffusion tensor imaging studies showed abnormal diffusion within white matter tracts commonly associated with traumatic brain injury, including the corpus callosum (8 of the 18) and superior longitudinal fasciculus (8 of the 18). Resting-state fMRI studies reported a variety of functional network differences. Other functional imaging studies showed diffuse changes in activity, especially in the frontal, parietal, temporal, and cingulate regions. CONCLUSION:: Vast variation in the sample, design, and measurement features across studies precludes salient conclusions regarding the effectiveness of neuroimaging to assess outcomes and elucidate pathomechanisms. The inherent spatial heterogeneity of mild traumatic brain injury pathology presents a major challenge to meaningful convergence across and generalizable inferences. Approaches to standardize methodology and facilitate access to data and integration across studies hold promise for enhancing our understanding of this complex brain disorder, but can only bear fruit if they are actually consistently implemented.",
author = "Weiya Mu and Eva Catenaccio and Lipton, {Michael L.}",
year = "2016",
month = "3",
day = "28",
doi = "10.1097/HTR.0000000000000213",
language = "English (US)",
journal = "Journal of Head Trauma Rehabilitation",
issn = "0885-9701",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Neuroimaging in Blast-Related Mild Traumatic Brain Injury

AU - Mu, Weiya

AU - Catenaccio, Eva

AU - Lipton, Michael L.

PY - 2016/3/28

Y1 - 2016/3/28

N2 - OBJECTIVE:: To summarize imaging findings in blast-related mild traumatic brain injury. DESIGN:: Our structured review of the literature yielded 5 structural magnetic resonance imaging (sMRI), 18 diffusion tensor imaging, 9 functional magnetic resonance imaging (fMRI), 3 positron emission tomography, 4 magnetoencephalography, 2 electroencephalography, and 1 single-positron emission computerized tomography studies. RESULTS:: Four of the 5 sMRI studies reported decreased cortical thickness and decreased thalamus and amygdala volume. Diffusion tensor imaging studies showed abnormal diffusion within white matter tracts commonly associated with traumatic brain injury, including the corpus callosum (8 of the 18) and superior longitudinal fasciculus (8 of the 18). Resting-state fMRI studies reported a variety of functional network differences. Other functional imaging studies showed diffuse changes in activity, especially in the frontal, parietal, temporal, and cingulate regions. CONCLUSION:: Vast variation in the sample, design, and measurement features across studies precludes salient conclusions regarding the effectiveness of neuroimaging to assess outcomes and elucidate pathomechanisms. The inherent spatial heterogeneity of mild traumatic brain injury pathology presents a major challenge to meaningful convergence across and generalizable inferences. Approaches to standardize methodology and facilitate access to data and integration across studies hold promise for enhancing our understanding of this complex brain disorder, but can only bear fruit if they are actually consistently implemented.

AB - OBJECTIVE:: To summarize imaging findings in blast-related mild traumatic brain injury. DESIGN:: Our structured review of the literature yielded 5 structural magnetic resonance imaging (sMRI), 18 diffusion tensor imaging, 9 functional magnetic resonance imaging (fMRI), 3 positron emission tomography, 4 magnetoencephalography, 2 electroencephalography, and 1 single-positron emission computerized tomography studies. RESULTS:: Four of the 5 sMRI studies reported decreased cortical thickness and decreased thalamus and amygdala volume. Diffusion tensor imaging studies showed abnormal diffusion within white matter tracts commonly associated with traumatic brain injury, including the corpus callosum (8 of the 18) and superior longitudinal fasciculus (8 of the 18). Resting-state fMRI studies reported a variety of functional network differences. Other functional imaging studies showed diffuse changes in activity, especially in the frontal, parietal, temporal, and cingulate regions. CONCLUSION:: Vast variation in the sample, design, and measurement features across studies precludes salient conclusions regarding the effectiveness of neuroimaging to assess outcomes and elucidate pathomechanisms. The inherent spatial heterogeneity of mild traumatic brain injury pathology presents a major challenge to meaningful convergence across and generalizable inferences. Approaches to standardize methodology and facilitate access to data and integration across studies hold promise for enhancing our understanding of this complex brain disorder, but can only bear fruit if they are actually consistently implemented.

UR - http://www.scopus.com/inward/record.url?scp=84961891959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961891959&partnerID=8YFLogxK

U2 - 10.1097/HTR.0000000000000213

DO - 10.1097/HTR.0000000000000213

M3 - Article

JO - Journal of Head Trauma Rehabilitation

JF - Journal of Head Trauma Rehabilitation

SN - 0885-9701

ER -