Neuroimaging abnormalities in children with an apparent first unprovoked seizure

Shlomo Shinnar, Christine O'Dell, Robin Mitnick, Anne T. Berg, Solomon L. Moshe

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Objective: To determine the incidence and type of neuroimaging abnormalities in children presenting with a first seizure. Methods: In a prospective observational study, 411 children with a first afebrile seizure were seen between 1983 and 1992. Imaging studies were performed in 218 (53%). For this analysis we examined the most sensitive neuroimaging study performed which included 159 computed tomography scans and 59 magnetic resonance imagings (MRI). Results: Four children were found to have lesions requiring intervention (brain tumor in two, neurocysticercosis in two). The remaining 407 were enrolled in a follow-up study of children with a first unprovoked seizure. After a mean follow-up of > 10 years, none have developed clinical evidence of a tumor. In these 411 children, 45 (21%) of 218 imaging studies were abnormal. The most common abnormalities were focal encephalomalacia (n = 16) and cerebral dysgenesis (n = 11). Although children with partial seizures were more likely to be imaged (64%) than children with generalized seizures (43%) (P < 0.001), the fraction of abnormal imaging studies was similar in both groups. Six children with a normal neurological examination who were initially classified as cryptogenic were subsequently found to have errors of cerebral migration on MRI. The incidence of lesions requiring acute intervention in children presenting with a first seizure is low. A significant proportion will have neuroimaging abnormalities particularly on MRI. Conclusions: Neuroimaging should be considered in any child with a first seizure who does not have an idiopathic form of epilepsy.

Original languageEnglish (US)
Pages (from-to)261-269
Number of pages9
JournalEpilepsy Research
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2001

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Neuroimaging
Seizures
Magnetic Resonance Imaging
Encephalomalacia
Neurocysticercosis
Incidence
Neurologic Examination
Brain Neoplasms
Observational Studies
Epilepsy
Tomography
Prospective Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Neuroimaging abnormalities in children with an apparent first unprovoked seizure. / Shinnar, Shlomo; O'Dell, Christine; Mitnick, Robin; Berg, Anne T.; Moshe, Solomon L.

In: Epilepsy Research, Vol. 43, No. 3, 01.03.2001, p. 261-269.

Research output: Contribution to journalArticle

Shinnar, Shlomo ; O'Dell, Christine ; Mitnick, Robin ; Berg, Anne T. ; Moshe, Solomon L. / Neuroimaging abnormalities in children with an apparent first unprovoked seizure. In: Epilepsy Research. 2001 ; Vol. 43, No. 3. pp. 261-269.
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