Neurogenic- but not pharmacologic-induced erections are significantly altered by 3 months of experimental diabetes

J. Rehman, A. Melman, P. Brink, B. Grine, B. Walcott, G. J. Christ

Research output: Contribution to journalArticle

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Abstract

The goal of the present investigation was to examine the effects of experimental diabetes mellitus (DM) on neurogenic and myogenic mechanisms of erectile function in a rat model. A 3 month period of DM was induced in 2 month old male Fischer 344 rats by either intraperitoneal streptozotocin (STZ) injection (35 mg/kg; n=15), or by subtotal pancreatectomy (n=2), with age-matched control animals (n=13) run in parallel. The effects of DM on erectile function were assessed by monitoring intracavemous pressure (ICP) responses to electrical stimulation of the cavernous nerve and by intracorporal papaverine injection. After 3 months of DM, ICP responses to neurostimulation were significantly attenuated in both STZdiabetic and subtotal pancreatectomy animals, when compared to age-matched control animals; reflexes were also significantly diminished (p<0.05; Student's t test for unpaired samples). Immunostaining with synaptophysin, revealed a significant correlation between decreased neurostimulation and diminished parenchymal and perivascular synaptophysin immunoreactivity in the rat corpora. However, there were no detectable differences in papaverine-induced ICP responses between diabetic and age-matched control animals. These data suggest a differential effect of DM on neurogenic versus myogenic erectile mechanisms, and indicate that this is a promising model system for studying DM-related autonomie neuropathy.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

Medical problems
diabetes mellitus
diabetes
Diabetes Mellitus
Animals
Papaverine
Synaptophysin
Pancreatectomy
papaverine
Rats
Pressure
animals
Experimental Diabetes Mellitus
injection
Inbred F344 Rats
Streptozocin
Intraperitoneal Injections
peripheral nervous system diseases
streptozotocin
rats

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Rehman, J., Melman, A., Brink, P., Grine, B., Walcott, B., & Christ, G. J. (1996). Neurogenic- but not pharmacologic-induced erections are significantly altered by 3 months of experimental diabetes. FASEB Journal, 10(3).

Neurogenic- but not pharmacologic-induced erections are significantly altered by 3 months of experimental diabetes. / Rehman, J.; Melman, A.; Brink, P.; Grine, B.; Walcott, B.; Christ, G. J.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Rehman, J, Melman, A, Brink, P, Grine, B, Walcott, B & Christ, GJ 1996, 'Neurogenic- but not pharmacologic-induced erections are significantly altered by 3 months of experimental diabetes', FASEB Journal, vol. 10, no. 3.
Rehman, J. ; Melman, A. ; Brink, P. ; Grine, B. ; Walcott, B. ; Christ, G. J. / Neurogenic- but not pharmacologic-induced erections are significantly altered by 3 months of experimental diabetes. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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