Neurofibrillary changes, granulovacuolar bodies and argentophilic globules observed in tuberous sclerosis

Asao Hirano, Ricardo Tuazon, H. M. Zimmerman

Research output: Contribution to journalArticle

45 Scopus citations


A lesion of tuberous sclerosis was observed in the parietal cortex of a 13-year old girl. Numerous giant neurons in the affected areas contained Alzheimer's neurofibrillary tangles, granulovacuolar degeneration and argentophilic globules. These findings in tuberous sclerosis, insofar as we know, are new in the literature.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalActa neuropathologica
Issue number3
Publication statusPublished - Sep 1 1968



  • Aging Changes
  • Argentophilic Globules
  • Giant Neurons
  • Granulovacuolar Degeneration
  • Neurofibrillary Tangles
  • Tuberous Sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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