Abstract
Several classification systems for neuroendocrine tumors (NETs) exist, which use variable terminology and criteria for grading and staging. This variability in terminology can cause confusion and difficulty in recognizing which tumors are, in fact, members of this heterogeneous group of malignancies. The largest group of NETs, the gastroenteropancreatic NETs, has been well described and characterized; however, there are less-recognized extra-abdominal NETs that can arise from nearly any organ in the body. In this article, the clinical features and imaging appearances of the extra-abdominal NETs will be reviewed, compared, and contrasted. This diverse group consists of paragangliomas, Merkel cell carcinomas, esthesioneuroblastomas, NETs of the lung, and medullary thyroid carcinomas. Recognition of these tumors as part of the larger group of NETs is important for understanding how best to approach imaging for their diagnosis, staging, and potential treatment. Familiarity with the computed tomographic and magnetic resonance imaging appearances and the role of radionuclide imaging of these heterogeneous groups aids in the correct diagnosis and in treatment planning.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 898-914 |
| Number of pages | 17 |
| Journal | Journal of Computer Assisted Tomography |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 11 2014 |
| Externally published | Yes |
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Keywords
- BIRADS classification
- Breast carcinoma
- Lesion descriptors
- magnetic resonance imaging
- Scoring system
- Specificity
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Neuroendocrine tumors : Beyond the abdomen. / Jacobs, Melissa A.; Weinstein, Stefanie; Hope, Thomas A.; Aslam, Rizwan; Yee, Judy; Coakley, Fergus.
In: Journal of Computer Assisted Tomography, Vol. 38, No. 6, 11.12.2014, p. 898-914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroendocrine tumors
T2 - Beyond the abdomen
AU - Jacobs, Melissa A.
AU - Weinstein, Stefanie
AU - Hope, Thomas A.
AU - Aslam, Rizwan
AU - Yee, Judy
AU - Coakley, Fergus
PY - 2014/12/11
Y1 - 2014/12/11
N2 - Several classification systems for neuroendocrine tumors (NETs) exist, which use variable terminology and criteria for grading and staging. This variability in terminology can cause confusion and difficulty in recognizing which tumors are, in fact, members of this heterogeneous group of malignancies. The largest group of NETs, the gastroenteropancreatic NETs, has been well described and characterized; however, there are less-recognized extra-abdominal NETs that can arise from nearly any organ in the body. In this article, the clinical features and imaging appearances of the extra-abdominal NETs will be reviewed, compared, and contrasted. This diverse group consists of paragangliomas, Merkel cell carcinomas, esthesioneuroblastomas, NETs of the lung, and medullary thyroid carcinomas. Recognition of these tumors as part of the larger group of NETs is important for understanding how best to approach imaging for their diagnosis, staging, and potential treatment. Familiarity with the computed tomographic and magnetic resonance imaging appearances and the role of radionuclide imaging of these heterogeneous groups aids in the correct diagnosis and in treatment planning.
AB - Several classification systems for neuroendocrine tumors (NETs) exist, which use variable terminology and criteria for grading and staging. This variability in terminology can cause confusion and difficulty in recognizing which tumors are, in fact, members of this heterogeneous group of malignancies. The largest group of NETs, the gastroenteropancreatic NETs, has been well described and characterized; however, there are less-recognized extra-abdominal NETs that can arise from nearly any organ in the body. In this article, the clinical features and imaging appearances of the extra-abdominal NETs will be reviewed, compared, and contrasted. This diverse group consists of paragangliomas, Merkel cell carcinomas, esthesioneuroblastomas, NETs of the lung, and medullary thyroid carcinomas. Recognition of these tumors as part of the larger group of NETs is important for understanding how best to approach imaging for their diagnosis, staging, and potential treatment. Familiarity with the computed tomographic and magnetic resonance imaging appearances and the role of radionuclide imaging of these heterogeneous groups aids in the correct diagnosis and in treatment planning.
KW - BIRADS classification
KW - Breast carcinoma
KW - Lesion descriptors
KW - magnetic resonance imaging
KW - Scoring system
KW - Specificity
UR - http://www.scopus.com/inward/record.url?scp=84918556692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918556692&partnerID=8YFLogxK
U2 - 10.1097/RCT.0000000000000140
DO - 10.1097/RCT.0000000000000140
M3 - Article
C2 - 25162290
AN - SCOPUS:84918556692
VL - 38
SP - 898
EP - 914
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 6
ER -