Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

Rene S. Kahn; Gregory M. Asnis; Scott Wetzler; Herman M. van Praag

doi:10.1007/BF00216062

Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

Rene S. Kahn, Gregory M. Asnis, Scott Wetzler, Herman M. van Praag

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.

Original language	English (US)
Pages (from-to)	360-364
Number of pages	5
Journal	Psychopharmacology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1007/BF00216062
State	Published - Nov 1988

Keywords

Anxiety
Cortisol
MCPP
Panic disorder
Receptor hypersensitivity
Serotonin

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00216062

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title = "Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder",

abstract = "Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.",

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AU - Kahn, Rene S.

AU - Asnis, Gregory M.

AU - Wetzler, Scott

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KW - Cortisol

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KW - Receptor hypersensitivity

KW - Serotonin

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Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

Abstract

Keywords

ASJC Scopus subject areas

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