Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

Rene S. Kahn, Gregory M. Asnis, Scott Wetzler, Herman M. van Praag

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalPsychopharmacology
Volume96
Issue number3
DOIs
StatePublished - Nov 1988

Fingerprint

Serotonin Receptors
Panic Disorder
Hydrocortisone
Hypersensitivity
Anxiety
Placebos
Depression
piperazine

Keywords

  • Anxiety
  • Cortisol
  • MCPP
  • Panic disorder
  • Receptor hypersensitivity
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. / Kahn, Rene S.; Asnis, Gregory M.; Wetzler, Scott; van Praag, Herman M.

In: Psychopharmacology, Vol. 96, No. 3, 11.1988, p. 360-364.

Research output: Contribution to journalArticle

Kahn, Rene S. ; Asnis, Gregory M. ; Wetzler, Scott ; van Praag, Herman M. / Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. In: Psychopharmacology. 1988 ; Vol. 96, No. 3. pp. 360-364.
@article{1b83fc0fcfce433e8f29737cc878600e,
title = "Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder",
abstract = "Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.",
keywords = "Anxiety, Cortisol, MCPP, Panic disorder, Receptor hypersensitivity, Serotonin",
author = "Kahn, {Rene S.} and Asnis, {Gregory M.} and Scott Wetzler and {van Praag}, {Herman M.}",
year = "1988",
month = "11",
doi = "10.1007/BF00216062",
language = "English (US)",
volume = "96",
pages = "360--364",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder

AU - Kahn, Rene S.

AU - Asnis, Gregory M.

AU - Wetzler, Scott

AU - van Praag, Herman M.

PY - 1988/11

Y1 - 1988/11

N2 - Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.

AB - Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.

KW - Anxiety

KW - Cortisol

KW - MCPP

KW - Panic disorder

KW - Receptor hypersensitivity

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0023729246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023729246&partnerID=8YFLogxK

U2 - 10.1007/BF00216062

DO - 10.1007/BF00216062

M3 - Article

C2 - 2906153

AN - SCOPUS:0023729246

VL - 96

SP - 360

EP - 364

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 3

ER -