Neurocognitive, Social-Behavioral, and Adaptive Functioning in Preschool Children with Mild to Moderate Kidney Disease

Stephen R. Hooper, Arlene C. Gerson, Rebecca J. Johnson, Susan R. Mendley, Shlomo Shinnar, Marc B. Lande, Matthew B. Matheson, Debbie S. Gipson, Bruce Morgenstern, Bradley A. Warady, Susan L. Furth

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10 Scopus citations

Abstract

OBJECTIVE:: The negative impact of end-stage kidney disease on cognitive function in children is well established, but no studies have examined the neurocognitive, social-behavioral, and adaptive behavior skills of preschool children with mild to moderate chronic kidney disease (CKD). METHOD:: Participants included 124 preschool children with mild to moderate CKD, aged 12 to 68 months (median = 3.7 years), and an associated mean glomerular filtration rate (GFR) of 50.0 mL·min·1.73 m. In addition to level of function and percent of participants scoring ≥1 SD below the test mean, regression models examined the associations between biomarkers of CKD (GFR, anemia, hypertension, seizures, and abnormal birth history), and developmental level/IQ, attention regulation, and parent ratings of executive functions, social-behavior, and adaptive behaviors. RESULTS:: Median scores for all measures were in the average range; however, 27% were deemed at risk for a developmental level/IQ

Original languageEnglish (US)
JournalJournal of Developmental and Behavioral Pediatrics
DOIs
StateAccepted/In press - Feb 17 2016

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Hooper, S. R., Gerson, A. C., Johnson, R. J., Mendley, S. R., Shinnar, S., Lande, M. B., Matheson, M. B., Gipson, D. S., Morgenstern, B., Warady, B. A., & Furth, S. L. (Accepted/In press). Neurocognitive, Social-Behavioral, and Adaptive Functioning in Preschool Children with Mild to Moderate Kidney Disease. Journal of Developmental and Behavioral Pediatrics. https://doi.org/10.1097/DBP.0000000000000267