Abstract
Nuclear magnetic resonance (NMR) imaging shows promise in the measurement of human cerebral blood flow (CBF) in that nonradioactive indicators may be used. Our earlier investigations with trifluoromethane (FC-23) gas have shown that this compound can be used to safely and effectively measure CBF in anesthetized animal models. In this Phase I dose-escalation study we set out to determine the maximal tolerated concentration (MTC) of FC-23 in normal healthy male volunteers and to assess its feasibility as an NMR indicator. Five subjects were exposed in a blinded fashion to escalating concentrations of FC-23 between 10% and 60%, randomly interleaved with exposures to both room air and 40% nitrous oxide. On each study day, the subjects breathed the test gas for eight pulses of 3 min each with 2-min.
Original language | English (US) |
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Pages (from-to) | 221-229 |
Number of pages | 9 |
Journal | Journal of Toxicology and Environmental Health |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Toxicology
- Pollution