TY - JOUR
T1 - Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia
AU - Sheelakumari, Raghavan
AU - Bineesh, Cheminnikara
AU - Varghese, Tinu
AU - Kesavadas, Chandrasekharan
AU - Verghese, Joe
AU - Mathuranath, Pavagada S.
N1 - Funding Information:
This study was supported by grants provided by the National Institute on Aging (NIA), USA (grant no. R21AG029799 to JV and R01AG039330–01) to PSM.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Neuroanatomical correlates of apathy and disinhibition, behavioral abnormalities in behavioral variant Frontotemporal dementia (bvFTD) remain unclear. In this study 45 participants (25 bvFTD patients and 20 controls) provided data on clinical, neuropsychological, behavioral (on Frontal Systems Behavior (FrSBe) Scale), cortical volume (on voxel-based morphometry (VBM)) and tract based spatial fractional anisotropy ((FA) on magnetic resonance imaging (MRI), allowing examination of the neural correlates of apathy and disinhibition. The patients with bvFTD had predominant grey matter loss and corresponding white matter fractional anisotropy reduction in the frontal and temporal lobe compared to the controls. Grey matter loss in frontal, temporal and limbic structures correlated with apathy and degeneration in temporal limbic brain areas correlated with disinhibition. FA changes in inferior fronto-occipital fasciculus and forceps minor correlated with apathy and fibre integrity changes in the superior longitudinal fasciculus correlated with disinhibition. The current study suggests that apathy and disinhibition arises due to changes in the frontal, temporal and limbic brain areas in bvFTD.
AB - Neuroanatomical correlates of apathy and disinhibition, behavioral abnormalities in behavioral variant Frontotemporal dementia (bvFTD) remain unclear. In this study 45 participants (25 bvFTD patients and 20 controls) provided data on clinical, neuropsychological, behavioral (on Frontal Systems Behavior (FrSBe) Scale), cortical volume (on voxel-based morphometry (VBM)) and tract based spatial fractional anisotropy ((FA) on magnetic resonance imaging (MRI), allowing examination of the neural correlates of apathy and disinhibition. The patients with bvFTD had predominant grey matter loss and corresponding white matter fractional anisotropy reduction in the frontal and temporal lobe compared to the controls. Grey matter loss in frontal, temporal and limbic structures correlated with apathy and degeneration in temporal limbic brain areas correlated with disinhibition. FA changes in inferior fronto-occipital fasciculus and forceps minor correlated with apathy and fibre integrity changes in the superior longitudinal fasciculus correlated with disinhibition. The current study suggests that apathy and disinhibition arises due to changes in the frontal, temporal and limbic brain areas in bvFTD.
KW - Behavioral variant FTD
KW - Fractional anisotropy
KW - Frontal system Behavioral scale
KW - Inferior fronto-occipital fasciculus
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U2 - 10.1007/s11682-019-00150-3
DO - 10.1007/s11682-019-00150-3
M3 - Article
C2 - 31273672
AN - SCOPUS:85068826800
SN - 1931-7557
VL - 14
SP - 2004
EP - 2011
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 5
ER -
