Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

Sudarshana Purkayastha, Hai Zhang, Guo Zhang, Zaghloul Ahmed, Yi Wang, Dongsheng Cai

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Chronic endoplasmic reticulum (ER) stress was recently revealed to affect hypothalamic neuroendocrine pathways that regulate feeding and body weight. However, it remains unexplored whether brain ER stress could use a neural route to rapidly cause the peripheral disorders that underlie the development of type 2 diabetes (T2D) and the metabolic syndrome. Using a pharmacologic model that delivered ER stress inducer thapsigargin into the brain, this study demonstrated that a short-term brain ER stress over 3 d was sufficient to induce glucose intolerance, systemic and hepatic insulin resistance, and blood pressure (BP) increase. The collection of these changes was accompanied by elevated sympathetic tone and prevented by sympathetic suppression. Molecular studies revealed that acute induction of metabolic disorders via brain ER stress was abrogated by NF-κB inhibition in the hypothalamus. Therapeutic experiments further revealed that acute inhibition of brain ER stress with tauroursodeoxycholic acid (TUDCA) partially reversed obesity-associated metabolic and blood pressure disorders. In conclusion, ER stress in the brain represents a mediator of the sympathetic disorders that underlie the development of insulin resistance syndrome and T2D.

Original languageEnglish (US)
Pages (from-to)2939-2944
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number7
DOIs
StatePublished - Feb 15 2011

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Endoplasmic Reticulum Stress
Insulin
Blood Pressure
Brain
Type 2 Diabetes Mellitus
Insulin Resistance
Metabolic Brain Diseases
Thapsigargin
Glucose Intolerance
Hypothalamus
Obesity
Body Weight
Liver

ASJC Scopus subject areas

  • General

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Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. / Purkayastha, Sudarshana; Zhang, Hai; Zhang, Guo; Ahmed, Zaghloul; Wang, Yi; Cai, Dongsheng.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 7, 15.02.2011, p. 2939-2944.

Research output: Contribution to journalArticle

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