NETWORKS | The Substantia Nigra in the Control of Seizures

M. H. Scantlebury; A. S. Galanopoulou; J. Velíšková; S. L. Moshé

doi:10.1016/B978-012373961-2.00262-9

NETWORKS | The Substantia Nigra in the Control of Seizures

M. H. Scantlebury, A. S. Galanopoulou, J. Velíšková, S. L. Moshé

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The overall goal of research in many laboratories is to identify mechanisms involved in the suppression of seizures as a function of age and gender. Epidemiological studies suggest that early in life, the brain is very susceptible to seizures and especially status epilepticus (SE). The substantia nigra pars reticulata (SNR) is one of the brain sites critically involved in the control of seizures. Understanding the normal development of this endogenous system, as well as the spectrum and progressive nature of SE-induced changes in brain function, may have important implications in the design of treatments aimed at disease modification – particularly with respect to specific age groups in either gender.

Original language	English (US)
Title of host publication	Encyclopedia of Basic Epilepsy Research
Publisher	Elsevier
Pages	846-854
Number of pages	9
ISBN (Electronic)	9780123739612
DOIs	https://doi.org/10.1016/B978-012373961-2.00262-9
State	Published - Jan 1 2009

Keywords

Autoradiography
Basal ganglia
Chloride cotransporter
Development
Epilepsy
Estrogen
GABA
GABA receptor
Glucose uptake
Inhibition
Muscimol
Seizure suppression
Status epilepticus (SE)
Substantia nigra
Substantia nigra pars reticulate
Testosterone

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-012373961-2.00262-9

Cite this

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abstract = "The overall goal of research in many laboratories is to identify mechanisms involved in the suppression of seizures as a function of age and gender. Epidemiological studies suggest that early in life, the brain is very susceptible to seizures and especially status epilepticus (SE). The substantia nigra pars reticulata (SNR) is one of the brain sites critically involved in the control of seizures. Understanding the normal development of this endogenous system, as well as the spectrum and progressive nature of SE-induced changes in brain function, may have important implications in the design of treatments aimed at disease modification – particularly with respect to specific age groups in either gender.",

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AU - Galanopoulou, A. S.

AU - Velíšková, J.

AU - Moshé, S. L.

PY - 2009/1/1

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KW - Autoradiography

KW - Basal ganglia

KW - Chloride cotransporter

KW - Development

KW - Epilepsy

KW - Estrogen

KW - GABA

KW - GABA receptor

KW - Glucose uptake

KW - Inhibition

KW - Muscimol

KW - Seizure suppression

KW - Status epilepticus (SE)

KW - Substantia nigra

KW - Substantia nigra pars reticulate

KW - Testosterone

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BT - Encyclopedia of Basic Epilepsy Research

PB - Elsevier

ER -

NETWORKS | The Substantia Nigra in the Control of Seizures

Abstract

Keywords

ASJC Scopus subject areas

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