Neto1 and Neto2: Auxiliary subunits that determine key properties of native kainate receptors

Susumu Tomita, Pablo E. Castillo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) that mediate excitatory synaptic transmission, regulate neurotransmitter release, and show a remarkably selective distribution in the brain. Compared to other iGluRs, the precise contribution of KARs to brain function is less understood. Unlike recombinant KARs, native KARs exhibit characteristically slow channel kinetics. The underlying explanation for this dissimilar kinetics has remained elusive until recently. New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and high affinity for agonist. Whether these auxiliary subunits regulate KAR trafficking and targeting at the synapse is less clear. By regulating channel gating, Neto1 and Neto2 can increase the diversity of KAR functional properties. These auxiliary subunits may represent a starting point for a better understanding of the role played by neuronal KARs under normal and pathological conditions, but also, they may provide an alternative target for the development of new drugs regulating KARs and brain function.

Original languageEnglish (US)
Pages (from-to)2217-2223
Number of pages7
JournalJournal of Physiology
Volume590
Issue number10
DOIs
StatePublished - May 2012

Fingerprint

Kainic Acid Receptors
Ionotropic Glutamate Receptors
Brain
Neurotransmitter Receptor
Synaptic Transmission
Synapses
Neurotransmitter Agents

ASJC Scopus subject areas

  • Physiology

Cite this

Neto1 and Neto2 : Auxiliary subunits that determine key properties of native kainate receptors. / Tomita, Susumu; Castillo, Pablo E.

In: Journal of Physiology, Vol. 590, No. 10, 05.2012, p. 2217-2223.

Research output: Contribution to journalArticle

@article{d4535fe5b00c4ccaa57c414dd6c0ffc6,
title = "Neto1 and Neto2: Auxiliary subunits that determine key properties of native kainate receptors",
abstract = "Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) that mediate excitatory synaptic transmission, regulate neurotransmitter release, and show a remarkably selective distribution in the brain. Compared to other iGluRs, the precise contribution of KARs to brain function is less understood. Unlike recombinant KARs, native KARs exhibit characteristically slow channel kinetics. The underlying explanation for this dissimilar kinetics has remained elusive until recently. New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and high affinity for agonist. Whether these auxiliary subunits regulate KAR trafficking and targeting at the synapse is less clear. By regulating channel gating, Neto1 and Neto2 can increase the diversity of KAR functional properties. These auxiliary subunits may represent a starting point for a better understanding of the role played by neuronal KARs under normal and pathological conditions, but also, they may provide an alternative target for the development of new drugs regulating KARs and brain function.",
author = "Susumu Tomita and Castillo, {Pablo E.}",
year = "2012",
month = "5",
doi = "10.1113/jphysiol.2011.221101",
language = "English (US)",
volume = "590",
pages = "2217--2223",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Neto1 and Neto2

T2 - Auxiliary subunits that determine key properties of native kainate receptors

AU - Tomita, Susumu

AU - Castillo, Pablo E.

PY - 2012/5

Y1 - 2012/5

N2 - Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) that mediate excitatory synaptic transmission, regulate neurotransmitter release, and show a remarkably selective distribution in the brain. Compared to other iGluRs, the precise contribution of KARs to brain function is less understood. Unlike recombinant KARs, native KARs exhibit characteristically slow channel kinetics. The underlying explanation for this dissimilar kinetics has remained elusive until recently. New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and high affinity for agonist. Whether these auxiliary subunits regulate KAR trafficking and targeting at the synapse is less clear. By regulating channel gating, Neto1 and Neto2 can increase the diversity of KAR functional properties. These auxiliary subunits may represent a starting point for a better understanding of the role played by neuronal KARs under normal and pathological conditions, but also, they may provide an alternative target for the development of new drugs regulating KARs and brain function.

AB - Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) that mediate excitatory synaptic transmission, regulate neurotransmitter release, and show a remarkably selective distribution in the brain. Compared to other iGluRs, the precise contribution of KARs to brain function is less understood. Unlike recombinant KARs, native KARs exhibit characteristically slow channel kinetics. The underlying explanation for this dissimilar kinetics has remained elusive until recently. New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and high affinity for agonist. Whether these auxiliary subunits regulate KAR trafficking and targeting at the synapse is less clear. By regulating channel gating, Neto1 and Neto2 can increase the diversity of KAR functional properties. These auxiliary subunits may represent a starting point for a better understanding of the role played by neuronal KARs under normal and pathological conditions, but also, they may provide an alternative target for the development of new drugs regulating KARs and brain function.

UR - http://www.scopus.com/inward/record.url?scp=84860995212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860995212&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.2011.221101

DO - 10.1113/jphysiol.2011.221101

M3 - Article

C2 - 22431337

AN - SCOPUS:84860995212

VL - 590

SP - 2217

EP - 2223

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 10

ER -