Nervous system degeneration produced by the industrial solvent methyl n butyl ketone

P. S. Spencer, H. H. Schaumburg, R. L. Raleigh, C. J. Terhaar

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Because of a number of cases of peripheral neuropathy that occurred in factory workers employed in a fabric printing plant in 1973, chronic inhalation experiments have been conducted using the printing ink solvents methyl n butyl ketone (MBK) and methyl iso butyl ketone (MIBK). After 4 mth of intermittent respiratory exposure to 1,300 parts per million (ppm) MBK, all 6 rats tested developed severe symmetric weakness in the hindlimbs. Morphological studies showed massive focal axonal enlargements containing abnormally large numbers of neurofilaments and dying back axonal degeneration in peripheral and central nerve fibers. Six rats similarly exposed for 5 mth to 1,500 ppm of MIBK showed minimal distal axonal change, but remained neurologically intact. The principal conclusion of this study is that MBK is a neurotoxin in rats.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalArchives of Neurology
Volume32
Issue number4
StatePublished - 1975

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Methyl n-Butyl Ketone
Hexanones
Nervous System
Printing
Ink
Intermediate Filaments
Neurotoxins
Peripheral Nervous System Diseases
Hindlimb
Peripheral Nerves
Nerve Fibers
Inhalation
Degeneration
Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spencer, P. S., Schaumburg, H. H., Raleigh, R. L., & Terhaar, C. J. (1975). Nervous system degeneration produced by the industrial solvent methyl n butyl ketone. Archives of Neurology, 32(4), 219-222.

Nervous system degeneration produced by the industrial solvent methyl n butyl ketone. / Spencer, P. S.; Schaumburg, H. H.; Raleigh, R. L.; Terhaar, C. J.

In: Archives of Neurology, Vol. 32, No. 4, 1975, p. 219-222.

Research output: Contribution to journalArticle

Spencer, PS, Schaumburg, HH, Raleigh, RL & Terhaar, CJ 1975, 'Nervous system degeneration produced by the industrial solvent methyl n butyl ketone', Archives of Neurology, vol. 32, no. 4, pp. 219-222.
Spencer PS, Schaumburg HH, Raleigh RL, Terhaar CJ. Nervous system degeneration produced by the industrial solvent methyl n butyl ketone. Archives of Neurology. 1975;32(4):219-222.
Spencer, P. S. ; Schaumburg, H. H. ; Raleigh, R. L. ; Terhaar, C. J. / Nervous system degeneration produced by the industrial solvent methyl n butyl ketone. In: Archives of Neurology. 1975 ; Vol. 32, No. 4. pp. 219-222.
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