Nerve growth factor prevents toxic neuropathy in mice

Stuart C. Apfel, Richard B. Lipton, Joseph C. Arezzo, John A. Kessler

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Taxol is a promising new antitumor drug with therapeutic use that is limited by a toxic sensory neuropathy. Taxol is also cytotoxic to dorsal root ganglion neurons in vitro, but this effect is prevented by cotreatment with the trophic protein, nerve growth factor. We sought to develop an animal model and then to determine whether nerve growth factor can prevent taxol neuropathy in vivo. Administration of taxol to mice resulted in a profound sensory neuropathy characterized by decreases in dorsal root ganglion content of the peptide neurotransmitter, substance P, elevated threshold to thermally induced pain, and diminished amplitude of the compound action potential in the caudal nerve. Coadministration of nerve growth factor prevented all of these signs of neurotoxicity. These findings suggest that administration of nerve growth factor may prevent certain toxic sensory neuropathies.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalAnnals of Neurology
Volume29
Issue number1
StatePublished - Jan 1991

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Poisons
Nerve Growth Factor
Paclitaxel
Spinal Ganglia
Therapeutic Uses
Substance P
Antineoplastic Agents
Action Potentials
Neurotransmitter Agents
Animal Models
Neurons
Pain
Peptides
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nerve growth factor prevents toxic neuropathy in mice. / Apfel, Stuart C.; Lipton, Richard B.; Arezzo, Joseph C.; Kessler, John A.

In: Annals of Neurology, Vol. 29, No. 1, 01.1991, p. 87-90.

Research output: Contribution to journalArticle

Apfel, Stuart C. ; Lipton, Richard B. ; Arezzo, Joseph C. ; Kessler, John A. / Nerve growth factor prevents toxic neuropathy in mice. In: Annals of Neurology. 1991 ; Vol. 29, No. 1. pp. 87-90.
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