Abstract
The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-15 |
| Number of pages | 5 |
| Journal | Neurotoxicology and Teratology |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
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Keywords
- Caffeine
- Muscle action potential
- Nerve conduction velocity
- Neuromuscular toxicity
- Peripheral neuromuscular function
- Synaptic fatigue
ASJC Scopus subject areas
- Neuroscience(all)
- Cellular and Molecular Neuroscience
- Toxicology
Cite this
Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats. / Raya, ángel; Cuervo, Ana Maria; Macian-Juan, Fernando; Romero, Francisco Javier; Romá, Joaquín.
In: Neurotoxicology and Teratology, Vol. 16, No. 1, 1994, p. 11-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats
AU - Raya, ángel
AU - Cuervo, Ana Maria
AU - Macian-Juan, Fernando
AU - Romero, Francisco Javier
AU - Romá, Joaquín
PY - 1994
Y1 - 1994
N2 - The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.
AB - The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.
KW - Caffeine
KW - Muscle action potential
KW - Nerve conduction velocity
KW - Neuromuscular toxicity
KW - Peripheral neuromuscular function
KW - Synaptic fatigue
UR - http://www.scopus.com/inward/record.url?scp=0028209284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028209284&partnerID=8YFLogxK
U2 - 10.1016/0892-0362(94)90003-5
DO - 10.1016/0892-0362(94)90003-5
M3 - Article
C2 - 8183184
AN - SCOPUS:0028209284
VL - 16
SP - 11
EP - 15
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
SN - 0892-0362
IS - 1
ER -