Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats

ángel Raya, Ana Maria Cuervo, Fernando Macian-Juan, Francisco Javier Romero, Joaquín Romá

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalNeurotoxicology and Teratology
Volume16
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Neural Conduction
Caffeine
Synaptic Transmission
Action Potentials
Muscle
Rats
Muscles
Animals
Drinking Water
Tail
Skeletal Muscle
Recovery

Keywords

  • Caffeine
  • Muscle action potential
  • Nerve conduction velocity
  • Neuromuscular toxicity
  • Peripheral neuromuscular function
  • Synaptic fatigue

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats. / Raya, ángel; Cuervo, Ana Maria; Macian-Juan, Fernando; Romero, Francisco Javier; Romá, Joaquín.

In: Neurotoxicology and Teratology, Vol. 16, No. 1, 1994, p. 11-15.

Research output: Contribution to journalArticle

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