TY - JOUR
T1 - Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats
AU - Raya, ángel
AU - Cuervo, Ana María
AU - Macián, Fernando
AU - Romero, Francisco Javier
AU - Romá, Joaquín
N1 - Funding Information:
ACKNOWLEDGEMENTS We are thankful for the advice and suggestions of G. T. Sdez and the late Dr. A. Jordd. We also thank B. Sofia for his helpful scientific criticism and to C. Avellaneda for his expert technical assistance. This work was partially supported by Grant No. 92/0403 from the FISS and PM92/0146 from the DGICYT (Spain). AR is a research fellow of the Conselleria de Cultura, Educaci6 i Ci~ncia de la Generalitat Valenciana. A.M.C. and F.M. are research fellows of the Ministerio de Educaci6n y Ciencia.
PY - 1994
Y1 - 1994
N2 - The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.
AB - The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.
KW - Caffeine
KW - Muscle action potential
KW - Nerve conduction velocity
KW - Neuromuscular toxicity
KW - Peripheral neuromuscular function
KW - Synaptic fatigue
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U2 - 10.1016/0892-0362(94)90003-5
DO - 10.1016/0892-0362(94)90003-5
M3 - Article
C2 - 8183184
AN - SCOPUS:0028209284
VL - 16
SP - 11
EP - 15
JO - Neurobehavioral toxicology
JF - Neurobehavioral toxicology
SN - 0892-0362
IS - 1
ER -