Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats

ángel Raya; Ana María Cuervo; Fernando Macián; Francisco Javier Romero; Joaquín Romá

doi:10.1016/0892-0362(94)90003-5

Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats

ángel Raya, Ana María Cuervo, Fernando Macián, Francisco Javier Romero, Joaquín Romá

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.

Original language	English (US)
Pages (from-to)	11-15
Number of pages	5
Journal	Neurotoxicology and Teratology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0892-0362(94)90003-5
State	Published - Jan 1 1994
Externally published	Yes

Keywords

Caffeine
Muscle action potential
Nerve conduction velocity
Neuromuscular toxicity
Peripheral neuromuscular function
Synaptic fatigue

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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10.1016/0892-0362(94)90003-5

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title = "Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats",

abstract = "The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.",

keywords = "Caffeine, Muscle action potential, Nerve conduction velocity, Neuromuscular toxicity, Peripheral neuromuscular function, Synaptic fatigue",

author = "{\'a}ngel Raya and Cuervo, {Ana Mar{\'i}a} and Fernando Maci{\'a}n and Romero, {Francisco Javier} and Joaqu{\'i}n Rom{\'a}",

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T1 - Nerve conduction velocity decrease and synaptic transmission alterations in caffeine-treated rats

AU - Raya, ángel

AU - Cuervo, Ana María

AU - Macián, Fernando

AU - Romero, Francisco Javier

AU - Romá, Joaquín

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The action of caffeine on peripheral neuromuscular function was studied by means of in vivo determinations of electrophysiological parameters, i.e., amplitude of extracellularly recorded muscle action potentials and nerve conduction velocity in the dorsal skeletal muscle and caudal nerve of the rat tail, respectively. Repeated exposure of the rats was carried out by adding caffeine to the drinking water for 10 days. Here we report the novel finding that motor nerve conduction velocity showed a significant decrease in caffeine-treated animals, whereas no change was observed in the amplitude of indirectly evoked extracellular muscle action potentials. The physiological recovery of the amplitude of the compound muscle action potential observed in nonintoxicated rats after high-frequency stimulation (10 Hz) was not observed in intoxicated animals and is also discussed.

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KW - Caffeine

KW - Muscle action potential

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KW - Neuromuscular toxicity

KW - Peripheral neuromuscular function

KW - Synaptic fatigue

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