Nephrotoxic serum nephritis with hypertension: Amelioration by antihypertensive therapy

J. Neugarten, B. Kaminetsky, H. Feiner, R. G. Schacht, D. T. Liu, D. S. Baldwin

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We have examined the effects of antihypertensive therapy on glomerular dynamics and on the clinical and morphologic features of a model of nephrotoxic serum nephritis (NSN) in which hypertension occurs. NSN was induced in uninephrectomized male Sprague Dawley rats, which drank 0.9% sodium chloride ad libitum. One-half were assigned randomly to a treated group whose blood pressure was normalized on a regimen of reserpine, hydralazine, and hydrochlorothiazide. Hypertension continued throughout the 6 weeks of study in untreated rats (blood pressure 148 ± 5 vs. 103 ± 3 mm Hg in treated rats, P < 0.01). Urinary protein excretion was greater (437 ± 110 vs. 254 ± 81 mg/24 hr, P < 0.005), and serum albumin lower (1.6 ± 0.4 vs 2.9 ± 0.3 g/dl, P < 0.01) in hypertensive animals. Diffuse glomerular endo- and extracapillary proliferation and arteriolar medial hypertrophy were observed frequently in nephritic rats with untreated hypertension. By contrast, structural abnormalities were limited primarily to focal segmental proliferation involving fewer than one-third of glomeruli in the absence of vascular changes in treated normotensive rats. Micropuncture studies performed 8 to 16 days after induction of nephritis showed a reduction in glomerular capillary pressure (46 ± 1 vs. 55 ± 1 mm Hg, P < 0.001), glomerular plasma flow rate (115 ± 20 vs. 160 ± 20 nl/min, P < 0.01), and single nephron filtration rate (42 ± 4 vs. 56 ± 5 nl/min, P < 0.001) with antihypertensive treatment, suggesting that a hemodynamic mechanism may have been responsible for enhanced glomerular injury in the hypertensive nephritic animals.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalKidney international
Volume28
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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