Neonatal Candida parapsilosis meningitis and empyema related to epidural migration of a central venous catheter

J. Elliot Carter, Javier A. Laurini, Tara N. Evans, Benjamin Estrada

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Candida parapsilosis is an extremely rare cause of meningitis. We report the case of a neonate born at 26 + 4 weeks of gestation who was admitted to the neonatal intensive care unit at our institution due to respiratory immaturity. During the course of a 3-month hospitalization, the neonate developed fever and lethargy. A lumbar puncture revealed milky-white, turbid cerebrospinal fluid which contained many nucleated cells, mostly neutrophils. Microscopic examination of the cerebrospinal fluid revealed marked acute inflammation and fungal yeast forms, and cultures of the cerebrospinal fluid and peripheral blood yielded C. parapsilosis. Imaging studies subsequently revealed a subdural empyema related to epidural migration of a central venous catheter (CVL). The neonate received extended therapy with amphotericin B and fluconazole. He responded favorably to therapy and was discharged 3 months after birth. This case underscores the clinical importance of the recognition and treatment of a potentially lethal fungal pathogen of the central nervous system and the need for awareness of complications resulting from CVL malposition.

Original languageEnglish (US)
Pages (from-to)614-618
Number of pages5
JournalClinical Neurology and Neurosurgery
Volume110
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Candida parapsilosis
  • Catheter
  • Empyema
  • Epidural
  • Meningitis
  • Venous

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Neonatal Candida parapsilosis meningitis and empyema related to epidural migration of a central venous catheter'. Together they form a unique fingerprint.

Cite this