Negative consequences of glycation

M. Brownlee

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

The Diabetes Control and Complications Trial (DCCT) established unequivocally that the effects of inadequate insulin action (as monitored by the level of hyperglycemia) are associated with the incidence and progression of diabetic retinopathy, nephropathy, and neuropathy. How does hyperglycemia induce the functional and morphologic changes that characterize diabetic complications? Increasing evidence points to a major role for sugar-derived advanced glycation end products (AGEs), which form inside and outside cells as a function of glucose concentration. Recent work in this area supports a central role for reactive oxygen species (ROS) in both the formation of AGEs, and in AGE-induced pathologic alterations in gene expression. Inhibition of ROS may also be centrally important in the action of drugs that prevent complications in diabetic animal models. (C) 2000 Saunders Company.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume49
Issue number2 SUPPL. 1
StatePublished - 2000

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Diabetes Complications
Hyperglycemia
Reactive Oxygen Species
Advanced Glycosylation End Products
Diabetic Neuropathies
Diabetic Nephropathies
Diabetic Retinopathy
Animal Models
Insulin
Gene Expression
Glucose
Incidence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Negative consequences of glycation. / Brownlee, M.

In: Metabolism: Clinical and Experimental, Vol. 49, No. 2 SUPPL. 1, 2000, p. 9-13.

Research output: Contribution to journalArticle

Brownlee, M 2000, 'Negative consequences of glycation', Metabolism: Clinical and Experimental, vol. 49, no. 2 SUPPL. 1, pp. 9-13.
Brownlee, M. / Negative consequences of glycation. In: Metabolism: Clinical and Experimental. 2000 ; Vol. 49, No. 2 SUPPL. 1. pp. 9-13.
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