Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

International epidemiology Databases to Evaluate AIDS (IeDEA)

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1 Scopus citations

Abstract

Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC.

Original languageEnglish (US)
Article numbere00513
JournalAntimicrobial agents and chemotherapy
Volume64
Issue number11
DOIs
StatePublished - Oct 2020

Keywords

  • Delamanid
  • Drug resistance
  • Mutations
  • Mycobacterium tuberculosis
  • Natural polymorphism
  • Resistance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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