Natural immunity to dust mites in patients with chronic rhinosinusitis

Tilo Freudenberger, Joseph N. Grizzanti, David L. Rosenstreich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68% exhibiting a positive immediate skin test reaction and 41% exhibiting elevated levels of mite-specific serum IgE; 72% of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.

Original languageEnglish (US)
Pages (from-to)855-862
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume82
Issue number5 PART 1
DOIs
StatePublished - 1988

Fingerprint

Mites
Dust
Innate Immunity
Asthma
Immunoglobulin G
Immunity
Dermatophagoides Antigens
Immunoglobulin Isotypes
Skin Tests
Serum
Immunoglobulin E
Research Design
Antigens

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Natural immunity to dust mites in patients with chronic rhinosinusitis. / Freudenberger, Tilo; Grizzanti, Joseph N.; Rosenstreich, David L.

In: The Journal of Allergy and Clinical Immunology, Vol. 82, No. 5 PART 1, 1988, p. 855-862.

Research output: Contribution to journalArticle

Freudenberger, Tilo ; Grizzanti, Joseph N. ; Rosenstreich, David L. / Natural immunity to dust mites in patients with chronic rhinosinusitis. In: The Journal of Allergy and Clinical Immunology. 1988 ; Vol. 82, No. 5 PART 1. pp. 855-862.
@article{6dc0fb28ce124e08873482b8f2125317,
title = "Natural immunity to dust mites in patients with chronic rhinosinusitis",
abstract = "Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68{\%} exhibiting a positive immediate skin test reaction and 41{\%} exhibiting elevated levels of mite-specific serum IgE; 72{\%} of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.",
author = "Tilo Freudenberger and Grizzanti, {Joseph N.} and Rosenstreich, {David L.}",
year = "1988",
doi = "10.1016/0091-6749(88)90090-5",
language = "English (US)",
volume = "82",
pages = "855--862",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5 PART 1",

}

TY - JOUR

T1 - Natural immunity to dust mites in patients with chronic rhinosinusitis

AU - Freudenberger, Tilo

AU - Grizzanti, Joseph N.

AU - Rosenstreich, David L.

PY - 1988

Y1 - 1988

N2 - Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68% exhibiting a positive immediate skin test reaction and 41% exhibiting elevated levels of mite-specific serum IgE; 72% of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.

AB - Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68% exhibiting a positive immediate skin test reaction and 41% exhibiting elevated levels of mite-specific serum IgE; 72% of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.

UR - http://www.scopus.com/inward/record.url?scp=0024231910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024231910&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(88)90090-5

DO - 10.1016/0091-6749(88)90090-5

M3 - Article

C2 - 3192869

AN - SCOPUS:0024231910

VL - 82

SP - 855

EP - 862

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5 PART 1

ER -