TY - JOUR
T1 - Natural immunity to dust mites in patients with chronic rhinosinusitis
AU - Freudenberger, Tilo
AU - Grizzanti, Joseph N.
AU - Rosenstreich, David L.
N1 - Funding Information:
From the Albert Einstein College of Medicine, Bronx, N.Y. Supported in part by National Institutes of Health Grants RO 1 AI-17934 and ROl AI-23169, funds from Hiram and Jeanne Grey. and the Verband der Chemischen Industrie, Frank-furt/Main, F&&al Republic of Germany. Received for publication Dec. 12, 1987. Accepted for publication April 30, 1988. Reprint requests: David L. Rosenstreich, MD, Albert Einstein Col-lege of Medicine, Dept. of Allergy and Immunology, Chanin 628, 1300 Morris Park Ave., Bronx, NY 10461.
PY - 1988/11
Y1 - 1988/11
N2 - Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68% exhibiting a positive immediate skin test reaction and 41% exhibiting elevated levels of mite-specific serum IgE; 72% of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.
AB - Chronic rhinosinusitis is an extremely common clinical problem of which the etiology is poorly understood. To understand the role of common environmental antigens in this disease, natural immunity to antigens derived from the house dust mite was evaluated in 22 adults with chronic rhinosinusitis and compared to a carefully matched group of patients with chronic asthma or to a group of normal individuals. Allergic reactivity to dust mites was very common in patients with chronic rhinosinusitis, with 68% exhibiting a positive immediate skin test reaction and 41% exhibiting elevated levels of mite-specific serum IgE; 72% of patients with rhinosinusitis also exhibited markedly elevated levels of mite-specific serum IgG, which were present in both mite-allergic and nonallergic patients. IgG titers were much higher in the group with rhinosinusitis than in patients with asthma, whereas allergic reactivity to dust mites was significantly higher in the patients with asthma. Mite-specific immunity was low or absent in the group of normal individuals. These findings demonstrate that natural immunity to dust mites is very common in patients with chronic rhinosinusitis and suggest that immunity to mites may be involved in this syndrome. Furthermore, the data indicate that there may be significant differences in the ability of patients with rhinosinusitis or asthma to produce mite-specific antibodies of the IgG class.
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U2 - 10.1016/0091-6749(88)90090-5
DO - 10.1016/0091-6749(88)90090-5
M3 - Article
C2 - 3192869
AN - SCOPUS:0024231910
SN - 0091-6749
VL - 82
SP - 855
EP - 862
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
IS - 5 PART 1
ER -