Natural cytotoxicity and interferon production in patients with recurrent respiratory papillomatosis

H. B. Naiman, Robert J. Ruben, A. T. Doyle, A. S. Kadish

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor immune responses stimulated by IFN. We have measured IFN production and natural cytotoxicity (NK activity) in nine patients with RRP, three of whom were receiving exogenous IFN at the time of testing. Production of IFN-γ induced by the T cell mitogen Staphylococcus enterotoxin A was normal in all patients. Production of IFN-α induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. Natural cytotoxicity against K562 target cells, both spontaneous and IFN-stimulated, was normal in all RRP patients tested. Thus, we have shown that the NK-IFN system was intact in untreated patients with RRP. IFN-α production in the RRP patients on IFN therapy was low. The significance of these findings is discussed.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume93
Issue number5 I
StatePublished - 1984

Fingerprint

Interferons
Recurrent respiratory papillomatosis
Sendai virus
Newcastle disease virus
K562 Cells
Enterotoxins
Staphylococcus
Mitogens
Therapeutics
T-Lymphocytes

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Natural cytotoxicity and interferon production in patients with recurrent respiratory papillomatosis. / Naiman, H. B.; Ruben, Robert J.; Doyle, A. T.; Kadish, A. S.

In: Annals of Otology, Rhinology and Laryngology, Vol. 93, No. 5 I, 1984, p. 483-487.

Research output: Contribution to journalArticle

@article{d288fa07750949baa48b035c4d7e205a,
title = "Natural cytotoxicity and interferon production in patients with recurrent respiratory papillomatosis",
abstract = "The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor immune responses stimulated by IFN. We have measured IFN production and natural cytotoxicity (NK activity) in nine patients with RRP, three of whom were receiving exogenous IFN at the time of testing. Production of IFN-γ induced by the T cell mitogen Staphylococcus enterotoxin A was normal in all patients. Production of IFN-α induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. Natural cytotoxicity against K562 target cells, both spontaneous and IFN-stimulated, was normal in all RRP patients tested. Thus, we have shown that the NK-IFN system was intact in untreated patients with RRP. IFN-α production in the RRP patients on IFN therapy was low. The significance of these findings is discussed.",
author = "Naiman, {H. B.} and Ruben, {Robert J.} and Doyle, {A. T.} and Kadish, {A. S.}",
year = "1984",
language = "English (US)",
volume = "93",
pages = "483--487",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "5 I",

}

TY - JOUR

T1 - Natural cytotoxicity and interferon production in patients with recurrent respiratory papillomatosis

AU - Naiman, H. B.

AU - Ruben, Robert J.

AU - Doyle, A. T.

AU - Kadish, A. S.

PY - 1984

Y1 - 1984

N2 - The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor immune responses stimulated by IFN. We have measured IFN production and natural cytotoxicity (NK activity) in nine patients with RRP, three of whom were receiving exogenous IFN at the time of testing. Production of IFN-γ induced by the T cell mitogen Staphylococcus enterotoxin A was normal in all patients. Production of IFN-α induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. Natural cytotoxicity against K562 target cells, both spontaneous and IFN-stimulated, was normal in all RRP patients tested. Thus, we have shown that the NK-IFN system was intact in untreated patients with RRP. IFN-α production in the RRP patients on IFN therapy was low. The significance of these findings is discussed.

AB - The observation that interferon (IFN) therapy causes regression of lesions in some patients with recurrent respiratory papillomatosis (RRP) raises the possibilities that these patients may have abnormalities in endogenous IFN production or in antitumor immune responses stimulated by IFN. We have measured IFN production and natural cytotoxicity (NK activity) in nine patients with RRP, three of whom were receiving exogenous IFN at the time of testing. Production of IFN-γ induced by the T cell mitogen Staphylococcus enterotoxin A was normal in all patients. Production of IFN-α induced by two viruses (Sendai and Newcastle disease viruses) was normal in the six untreated patients, but significantly lower in the patients on IFN therapy. Natural cytotoxicity against K562 target cells, both spontaneous and IFN-stimulated, was normal in all RRP patients tested. Thus, we have shown that the NK-IFN system was intact in untreated patients with RRP. IFN-α production in the RRP patients on IFN therapy was low. The significance of these findings is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0021720745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021720745&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 483

EP - 487

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 5 I

ER -