Natural autoantibodies in sera of patients with Gaucher's disease

Y. Shoenfeld, A. Beresovski, D. Zharhary, Y. Tomer, M. Swissa, E. Sela, A. Zimran, S. Zevin, B. Gilburd, M. Blank

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42 Scopus citations

Abstract

Gaucher's disease (GD) is associated with hyperactivity of the immune system, which manifests by polyclonal hypergammaglobulinemia and an increased incidence of monoclonal gammopathies in GD patients. We analyzed sera of 43 patients with GD for the presence of autoantibodies against 14 autoantigens. The results demonstrated a significant increase in the incidence of all autoantibodies tested, ranging from 11% for anti-RNP, pyruvate dehydrogenase (PDH), and DNA antibodies to 57% for rheumatoid factor. The autoantibodies were of all three isotypes, namely, IgG, IgM, and IgA. There was no correlation between the levels of immunoglobulins in the serum and the titer of autoantibodies found. Immunization of naive mice with a pool of purified anti-DNA antibodies form GD patients did not result in induction of experimental systemic lupus erythematosus (SLE), suggesting that they may represent natural autoantibodies that are not pathogenic. In conclusion, we found high titers of natural, polyspecific, nonpathogenic autoantibodies in the sera of GD patients.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalJournal of Clinical Immunology
Volume15
Issue number6
DOIs
Publication statusPublished - Nov 1 1995
Externally publishedYes

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Keywords

  • Gaucher's disease
  • Natural autoantibodies
  • anti-DNA
  • autoimmunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Shoenfeld, Y., Beresovski, A., Zharhary, D., Tomer, Y., Swissa, M., Sela, E., ... Blank, M. (1995). Natural autoantibodies in sera of patients with Gaucher's disease. Journal of Clinical Immunology, 15(6), 363-372. https://doi.org/10.1007/BF01541326