Nanotoxicity overview: Nano-threat to susceptible populations

Yang Li, Yi Zhang, Bing Yan

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications.

Original languageEnglish (US)
Pages (from-to)3671-3697
Number of pages27
JournalInternational Journal of Molecular Sciences
Volume15
Issue number3
DOIs
StatePublished - Feb 28 2014
Externally publishedYes

Fingerprint

Nanoparticles
Population
Nanotechnology
nanoparticles
nanotechnology
Health risks
Nanostructured materials
Toxicity
Repair
Newborn Infant
Nanostructures
immunity
toxicity
hazards
health
Immunity
damage
Health

Keywords

  • Aged population
  • Disease
  • Health risk
  • Nanotoxicity
  • Susceptible populations

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Nanotoxicity overview : Nano-threat to susceptible populations. / Li, Yang; Zhang, Yi; Yan, Bing.

In: International Journal of Molecular Sciences, Vol. 15, No. 3, 28.02.2014, p. 3671-3697.

Research output: Contribution to journalReview article

@article{470adc321e20450db66055c6e7e92c73,
title = "Nanotoxicity overview: Nano-threat to susceptible populations",
abstract = "Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications.",
keywords = "Aged population, Disease, Health risk, Nanotoxicity, Susceptible populations",
author = "Yang Li and Yi Zhang and Bing Yan",
year = "2014",
month = "2",
day = "28",
doi = "10.3390/ijms15033671",
language = "English (US)",
volume = "15",
pages = "3671--3697",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Nanotoxicity overview

T2 - Nano-threat to susceptible populations

AU - Li, Yang

AU - Zhang, Yi

AU - Yan, Bing

PY - 2014/2/28

Y1 - 2014/2/28

N2 - Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications.

AB - Due to the increasing applications of nanomaterials and nanotechnology, potential danger of nanoparticle exposure has become a critical issue. However, recent nanotoxicity studies have mainly focused on the health risks to healthy adult population. The nanotoxicity effects on susceptible populations (such as pregnant, neonate, diseased, and aged populations) have been overlooked. Due to the alterations in physiological structures and functions in susceptible populations, they often suffer more damage from the same exposure. Thus, it is urgent to understand the effects of nanoparticle exposure on these populations. In order to fill this gap, the potential effects of nanoparticles to pregnant females, neonate, diseased, and aged population, as well as the possible underlying mechanisms are reviewed in this article. Investigations show that responses from susceptible population to nanoparticle exposure are often more severe. Reduced protection mechanism, compromised immunity, and impaired self-repair ability in these susceptible populations may contribute to the aggravated toxicity effects. This review will help minimize adverse effects of nanoparticles to susceptible population in future nanotechnology applications.

KW - Aged population

KW - Disease

KW - Health risk

KW - Nanotoxicity

KW - Susceptible populations

UR - http://www.scopus.com/inward/record.url?scp=84895436939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895436939&partnerID=8YFLogxK

U2 - 10.3390/ijms15033671

DO - 10.3390/ijms15033671

M3 - Review article

C2 - 24590128

AN - SCOPUS:84895436939

VL - 15

SP - 3671

EP - 3697

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 3

ER -