TY - JOUR
T1 - Nanomaterials for Wound Healing
AU - Mordorski, Breanne
AU - Prow, Tarl
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose of Review: Despite the emergence of various new wound care products, millions of people continue to suffer from complications associated with acute and chronic wounds. Nanomaterials offer a variety of strategies to accelerate wound closure and promote appropriate progression through the stages of healing, which will be detailed in this review. Recent Findings: The small size of nanomaterials enhances penetration and permeation of tissues and lends a large surface area-to-volume ratio, ideal for topical drug delivery. Furthermore, nanofibers may be utilized to create nanoscaffold wound dressings that simulate the topographic appearance of endogenous extracellular matrix, thereby stimulating wound reepithelialization and collagen production. Summary: Together, nanomaterials offer many approaches to reduce the morbidity associated with acute and chronic wounds, as demonstrated by a substantial body of pre-clinical data. Future investigations should aim to address the paucity of human clinical trial data, essential for translating wound-healing benefits from bench to bedside.
AB - Purpose of Review: Despite the emergence of various new wound care products, millions of people continue to suffer from complications associated with acute and chronic wounds. Nanomaterials offer a variety of strategies to accelerate wound closure and promote appropriate progression through the stages of healing, which will be detailed in this review. Recent Findings: The small size of nanomaterials enhances penetration and permeation of tissues and lends a large surface area-to-volume ratio, ideal for topical drug delivery. Furthermore, nanofibers may be utilized to create nanoscaffold wound dressings that simulate the topographic appearance of endogenous extracellular matrix, thereby stimulating wound reepithelialization and collagen production. Summary: Together, nanomaterials offer many approaches to reduce the morbidity associated with acute and chronic wounds, as demonstrated by a substantial body of pre-clinical data. Future investigations should aim to address the paucity of human clinical trial data, essential for translating wound-healing benefits from bench to bedside.
KW - Metal nanoparticles
KW - Nanomaterials
KW - Nanoscaffold wound dressings
KW - Small interfering RNA
KW - Topical drug delivery
KW - Wound healing
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U2 - 10.1007/s13671-016-0159-0
DO - 10.1007/s13671-016-0159-0
M3 - Review article
AN - SCOPUS:85048440271
SN - 2162-4933
VL - 5
SP - 278
EP - 286
JO - Current Dermatology Reports
JF - Current Dermatology Reports
IS - 4
ER -