N-Linked Glycans (N-Glycans)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

N-linked glycans (N-glycans) are covalently attached to glycoproteins during translation and translocation into the endoplasmic reticulum, and subsequently modified during glycoprotein transit through the secretory pathway. The most common consensus for attachment of an N-glycan is Asn-X(not Pro)-Ser/Thr. Although necessary, this consensus is not sufficient for N-glycan addition to occur. N-glycans have many different functions that may be independent of the glycoprotein to which they are attached, or may specifically affect its production and functions. The factors that govern optimal N-glycan attachment and maturation are encoded by ~300 genes. Mutations in these genes lead to Congenital Disorders of Glycosylation (CDG), rare diseases arising from mutations in genes involved in protein glycosylation.

Original languageEnglish (US)
Title of host publicationOrganizational Cell Biology
PublisherElsevier Inc.
Pages339-346s
Volume2
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2015

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Polysaccharides
Glycoproteins
Congenital Disorders of Glycosylation
Genes
Mutation
Secretory Pathway
Rare Diseases
Glycosylation
Endoplasmic Reticulum

Keywords

  • Cis-Golgi
  • Congenital disorders of glycosylation
  • Endoplasmic reticulum
  • Glycosidase
  • Glycosyltransferase
  • Medial-Golgi
  • N-glycan
  • N-linked
  • Nucleotide sugar
  • Trans-Golgi

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stanley, P. (2015). N-Linked Glycans (N-Glycans). In Organizational Cell Biology (Vol. 2, pp. 339-346s). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.20032-1

N-Linked Glycans (N-Glycans). / Stanley, Pamela.

Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. p. 339-346s.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stanley, P 2015, N-Linked Glycans (N-Glycans). in Organizational Cell Biology. vol. 2, Elsevier Inc., pp. 339-346s. https://doi.org/10.1016/B978-0-12-394447-4.20032-1
Stanley P. N-Linked Glycans (N-Glycans). In Organizational Cell Biology. Vol. 2. Elsevier Inc. 2015. p. 339-346s https://doi.org/10.1016/B978-0-12-394447-4.20032-1
Stanley, Pamela. / N-Linked Glycans (N-Glycans). Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. pp. 339-346s
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