N-cadherin expression in breast cancer: Correlation with an aggressive histologic variant - Invasive micropapillary carcinoma

Chandandeep Nagi, Mitchell Guttman, Shabnam Jaffer, Rui Qiao, Rinat Keren, Aymara Triana, Maomi Li, James Godbold, Ira J. Bleiweiss, Rachel Hazan

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Upregulation of N-cadherin in epithelial tumor cells has been shown to contribute to the invasive/metastatic phenotype. It remains however to be determined whether N-cadherin is increased in human breast cancers with enhanced malignant potential. We examined a large number of invasive breast cancer specimens (n=114) for N- and E-cadherin. These specimens compared invasive duct carcinomas (IDCs) of varying histologic grades with an aggressive subtype, invasive micropapillary carcinoma of the breast (MPAP), which has a high propensity for lymphatic invasion and lymph node metastasis. Staining scores for N- and E-cadherin were compared between non-MPAP and MPAP IDCs, and between the invasive and ductal carcinoma in situ (DCIS) of each IDC using statistical analysis. We found that N-cadherin was expressed in 76% of MPAP and 52% of non-MPAP carcinomas, and E-cadherin in 57% of MPAP and 36% of non-MPAP tumors. More MPAP (25%) compared to non-MPAP (5%) tumors expressed both cadherins. Of the two cadherins, N-cadherin was significantly associated with MPAP tumors (p=0.033) compared to E-cad (p=0.171). Moreover, in the majority of tumors that were positive for N-cadherin, the staining scores were increased in the IDC relative to intraductal components, and this effect was more dramatic in the MPAP carcinomas. This difference for N-cadherin was greater than the corresponding difference for E-cadherin in the MPAP group (p=0.005), whereas such changes were not significant in the non-MPAP group (p=0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.

Original languageEnglish (US)
Pages (from-to)225-235
Number of pages11
JournalBreast Cancer Research and Treatment
Volume94
Issue number3
DOIs
StatePublished - Dec 2005

Fingerprint

Cadherins
Breast Neoplasms
Carcinoma
Neoplasms
Staining and Labeling
Carcinoma, Intraductal, Noninfiltrating
Up-Regulation
Lymph Nodes
Epithelial Cells
Neoplasm Metastasis

Keywords

  • Breast cancer
  • Invasive micropapillary carcinoma
  • Metastasis
  • N-cadherin
  • Tumor aggressiveness

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

N-cadherin expression in breast cancer : Correlation with an aggressive histologic variant - Invasive micropapillary carcinoma. / Nagi, Chandandeep; Guttman, Mitchell; Jaffer, Shabnam; Qiao, Rui; Keren, Rinat; Triana, Aymara; Li, Maomi; Godbold, James; Bleiweiss, Ira J.; Hazan, Rachel.

In: Breast Cancer Research and Treatment, Vol. 94, No. 3, 12.2005, p. 225-235.

Research output: Contribution to journalArticle

Nagi, Chandandeep ; Guttman, Mitchell ; Jaffer, Shabnam ; Qiao, Rui ; Keren, Rinat ; Triana, Aymara ; Li, Maomi ; Godbold, James ; Bleiweiss, Ira J. ; Hazan, Rachel. / N-cadherin expression in breast cancer : Correlation with an aggressive histologic variant - Invasive micropapillary carcinoma. In: Breast Cancer Research and Treatment. 2005 ; Vol. 94, No. 3. pp. 225-235.
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AU - Qiao, Rui

AU - Keren, Rinat

AU - Triana, Aymara

AU - Li, Maomi

AU - Godbold, James

AU - Bleiweiss, Ira J.

AU - Hazan, Rachel

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