N-acetil-β-D-glicosaminidase como biomarcador precoce de disfunção renal para a exposição ocupacional ao chumbo inorgânico

Translated title of the contribution: N-acetyl-β-D-glucosaminidase as an early biomarker of renal dysfunction due to occupational exposure to inorganic lead

Leandro Nishikawa Gonçales, Mônica Maria Bastos Paoliello, Vanderly Janeiro, Miguel Machinski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: This study aimed to verify the enzymatic activity of N-acetyl-β-D-glucosaminidase (NAG) as a possible early biomarker of renal dysfunction due to occupational exposure to inorganic lead. Materials and methods: We selected a group of 30 males that had been exposed to inorganic lead in a battery factory in the state of Paraná. This group comprised those employees whose blood lead levels were below 40 mg/dl. The control group consisted of 15 healthy adults of similar age and gender compared with the exposed group. Blood lead concentrations, d-aminolevulinic acid levels and urinary NAG activity were measured. Results and discussion: It was shown that urinary NAG activity was significantly higher (p < 0.05, U test of Mann-Whitney) in the exposed group in comparison to the control group, and there was a significant negative correlation (p < 0.05, Spearman Rank Order correlation) between the biological indicator of lead exposure and urinary NAG activity. Conclusion: The results showed that the increase of urinary NAG activity may be used as an early biomarker of the exposure to inorganic lead.

Translated title of the contributionN-acetyl-β-D-glucosaminidase as an early biomarker of renal dysfunction due to occupational exposure to inorganic lead
Original languagePortuguese
Pages (from-to)241-247
Number of pages7
JournalJornal Brasileiro de Patologia e Medicina Laboratorial
Volume44
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Biomarker
  • Lead
  • N-acetyl-β-D-glucosaminidase
  • Occupational health
  • Urine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Clinical Biochemistry

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