Myocardial G proteins in murine Chagas' disease

Huan Huang, Herbert B. Tanowitz, John P. Bilezikian, Murray Wittner, Louis M. Weiss, Stephen A. Morris

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

G protein α subunits and their corresponding mRNA levels were determined in hearts obtained from mice infected with Trypanosoma cruzi, the etiologic agent of Chagas' disease. Protein and mRNA levels of the inhibitory G proteins G(αi2) and G(αi3) were increased at 21 and 30 days postinfection (PI). After 60 days, the abundance of protein and corresponding mRNA for G(αi2) and G(αi3) were no longer significantly different from uninfected mice. Twenty-one days after infection. G(αs) protein levels decreased markedly, but mRNA for the stimulatory protein did not change. Similar to the G(i) proteins, by 60 days differences in G(αs) protein between infected and uninfected mice were no longer evident. There was an increase in the magnitude of G(β) subunit protein 21 and 30 days PI as compared with uninfected mice. However, 60 days PI the G(β) subunit protein decreased to control levels. The close relationship between the infection-associated increase in G(αi) protein and mRNA suggests that control of protein expression is likely to be exerted at the transcription level. In contrast, control of infection-associated decrease in G(s) appears to be at the translational level.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalJournal of Parasitology
Volume83
Issue number4
DOIs
StatePublished - Aug 1997
Externally publishedYes

Fingerprint

Chagas disease
Chagas Disease
G-proteins
GTP-Binding Proteins
protein
mice
protein subunits
Protein Subunits
Proteins
proteins
Messenger RNA
Trypanosoma cruzi
infection
Infection Control
Infection
disease control
transcription (genetics)
protein synthesis
heart

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology
  • Microbiology

Cite this

Huang, H., Tanowitz, H. B., Bilezikian, J. P., Wittner, M., Weiss, L. M., & Morris, S. A. (1997). Myocardial G proteins in murine Chagas' disease. Journal of Parasitology, 83(4), 663-670. https://doi.org/10.2307/3284244

Myocardial G proteins in murine Chagas' disease. / Huang, Huan; Tanowitz, Herbert B.; Bilezikian, John P.; Wittner, Murray; Weiss, Louis M.; Morris, Stephen A.

In: Journal of Parasitology, Vol. 83, No. 4, 08.1997, p. 663-670.

Research output: Contribution to journalArticle

Huang, H, Tanowitz, HB, Bilezikian, JP, Wittner, M, Weiss, LM & Morris, SA 1997, 'Myocardial G proteins in murine Chagas' disease', Journal of Parasitology, vol. 83, no. 4, pp. 663-670. https://doi.org/10.2307/3284244
Huang H, Tanowitz HB, Bilezikian JP, Wittner M, Weiss LM, Morris SA. Myocardial G proteins in murine Chagas' disease. Journal of Parasitology. 1997 Aug;83(4):663-670. https://doi.org/10.2307/3284244
Huang, Huan ; Tanowitz, Herbert B. ; Bilezikian, John P. ; Wittner, Murray ; Weiss, Louis M. ; Morris, Stephen A. / Myocardial G proteins in murine Chagas' disease. In: Journal of Parasitology. 1997 ; Vol. 83, No. 4. pp. 663-670.
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