Myocardial electrical impedance responds to ischemia and reperfusion in humans

Roger Dzwonczyk, Carlos Del Rio, David A. Brown, Robert E. Michler, Randal K. Wolf, Michael B. Howie

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Myocardial electrical impedance (MEI) is correlated to ischemia and reperfusion of the hearth muscle. The entire body of work with MEI to this point has been carried out in animal subjects in vivo and excised tissue samples. In this study, we measured MEI clinically for the first time in human patients who were undergoing off-pump coronary aratery bypass (OPCAB) surgery. MEI was measured with a monitor designed in this laboratory and approved by the FDA for use on human subjects. Our patient population (n = 18) had a 70%-100% stenosis of the diseased coronary artery targeted for bypass. We measured NIEL continuously during surgery and at 3, 6, 24, and 72 h postoperatively from two temporary pacing electrodes attached to the heart muscle. Absolute baseline impedance ranged from 173 to 729 ω. MEI increased with occlusion of the diseased artery prior to bypass. The percent increase from baseline was inversely correlated to the percent stenosis of the diseased artery. MEI decreased below baseline immediately on reperfusion following bypass in all patients and continued decreasing over the measurement period. NIEI is a reliable clinical indicator of ischemia and reperfusion in humans and may indicate the effectiveness of coronary artery surgery. The parameter may have monitoring and diagnostic value in heart disease in humans.

Original languageEnglish (US)
Pages (from-to)2206-2209
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Volume51
Issue number12
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Acoustic impedance
Surgery
Muscle
Animals
Pumps
Tissue
Electrodes
Monitoring

Keywords

  • Ischemia
  • Myocardial electrical impedance
  • Reperfusion

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Myocardial electrical impedance responds to ischemia and reperfusion in humans. / Dzwonczyk, Roger; Del Rio, Carlos; Brown, David A.; Michler, Robert E.; Wolf, Randal K.; Howie, Michael B.

In: IEEE Transactions on Biomedical Engineering, Vol. 51, No. 12, 12.2004, p. 2206-2209.

Research output: Contribution to journalArticle

Dzwonczyk, Roger ; Del Rio, Carlos ; Brown, David A. ; Michler, Robert E. ; Wolf, Randal K. ; Howie, Michael B. / Myocardial electrical impedance responds to ischemia and reperfusion in humans. In: IEEE Transactions on Biomedical Engineering. 2004 ; Vol. 51, No. 12. pp. 2206-2209.
@article{9fdb148436e945b7a80518a6f7f640bf,
title = "Myocardial electrical impedance responds to ischemia and reperfusion in humans",
abstract = "Myocardial electrical impedance (MEI) is correlated to ischemia and reperfusion of the hearth muscle. The entire body of work with MEI to this point has been carried out in animal subjects in vivo and excised tissue samples. In this study, we measured MEI clinically for the first time in human patients who were undergoing off-pump coronary aratery bypass (OPCAB) surgery. MEI was measured with a monitor designed in this laboratory and approved by the FDA for use on human subjects. Our patient population (n = 18) had a 70{\%}-100{\%} stenosis of the diseased coronary artery targeted for bypass. We measured NIEL continuously during surgery and at 3, 6, 24, and 72 h postoperatively from two temporary pacing electrodes attached to the heart muscle. Absolute baseline impedance ranged from 173 to 729 ω. MEI increased with occlusion of the diseased artery prior to bypass. The percent increase from baseline was inversely correlated to the percent stenosis of the diseased artery. MEI decreased below baseline immediately on reperfusion following bypass in all patients and continued decreasing over the measurement period. NIEI is a reliable clinical indicator of ischemia and reperfusion in humans and may indicate the effectiveness of coronary artery surgery. The parameter may have monitoring and diagnostic value in heart disease in humans.",
keywords = "Ischemia, Myocardial electrical impedance, Reperfusion",
author = "Roger Dzwonczyk and {Del Rio}, Carlos and Brown, {David A.} and Michler, {Robert E.} and Wolf, {Randal K.} and Howie, {Michael B.}",
year = "2004",
month = "12",
doi = "10.1109/TBME.2004.834297",
language = "English (US)",
volume = "51",
pages = "2206--2209",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "12",

}

TY - JOUR

T1 - Myocardial electrical impedance responds to ischemia and reperfusion in humans

AU - Dzwonczyk, Roger

AU - Del Rio, Carlos

AU - Brown, David A.

AU - Michler, Robert E.

AU - Wolf, Randal K.

AU - Howie, Michael B.

PY - 2004/12

Y1 - 2004/12

N2 - Myocardial electrical impedance (MEI) is correlated to ischemia and reperfusion of the hearth muscle. The entire body of work with MEI to this point has been carried out in animal subjects in vivo and excised tissue samples. In this study, we measured MEI clinically for the first time in human patients who were undergoing off-pump coronary aratery bypass (OPCAB) surgery. MEI was measured with a monitor designed in this laboratory and approved by the FDA for use on human subjects. Our patient population (n = 18) had a 70%-100% stenosis of the diseased coronary artery targeted for bypass. We measured NIEL continuously during surgery and at 3, 6, 24, and 72 h postoperatively from two temporary pacing electrodes attached to the heart muscle. Absolute baseline impedance ranged from 173 to 729 ω. MEI increased with occlusion of the diseased artery prior to bypass. The percent increase from baseline was inversely correlated to the percent stenosis of the diseased artery. MEI decreased below baseline immediately on reperfusion following bypass in all patients and continued decreasing over the measurement period. NIEI is a reliable clinical indicator of ischemia and reperfusion in humans and may indicate the effectiveness of coronary artery surgery. The parameter may have monitoring and diagnostic value in heart disease in humans.

AB - Myocardial electrical impedance (MEI) is correlated to ischemia and reperfusion of the hearth muscle. The entire body of work with MEI to this point has been carried out in animal subjects in vivo and excised tissue samples. In this study, we measured MEI clinically for the first time in human patients who were undergoing off-pump coronary aratery bypass (OPCAB) surgery. MEI was measured with a monitor designed in this laboratory and approved by the FDA for use on human subjects. Our patient population (n = 18) had a 70%-100% stenosis of the diseased coronary artery targeted for bypass. We measured NIEL continuously during surgery and at 3, 6, 24, and 72 h postoperatively from two temporary pacing electrodes attached to the heart muscle. Absolute baseline impedance ranged from 173 to 729 ω. MEI increased with occlusion of the diseased artery prior to bypass. The percent increase from baseline was inversely correlated to the percent stenosis of the diseased artery. MEI decreased below baseline immediately on reperfusion following bypass in all patients and continued decreasing over the measurement period. NIEI is a reliable clinical indicator of ischemia and reperfusion in humans and may indicate the effectiveness of coronary artery surgery. The parameter may have monitoring and diagnostic value in heart disease in humans.

KW - Ischemia

KW - Myocardial electrical impedance

KW - Reperfusion

UR - http://www.scopus.com/inward/record.url?scp=9644257164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9644257164&partnerID=8YFLogxK

U2 - 10.1109/TBME.2004.834297

DO - 10.1109/TBME.2004.834297

M3 - Article

C2 - 15605871

AN - SCOPUS:9644257164

VL - 51

SP - 2206

EP - 2209

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

IS - 12

ER -