Myocardial electrical impedance responds to ischemia and reperfusion in humans

Roger Dzwonczyk, C. Del Rio, D. A. Brown, Robert E. Michler, R. K. Wolf, M. B. Howie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Myocardial electrical impedance (MEI) is correlated to ischemia and reperfusion of the heart muscle. The entire body of work with MEI to this point has been carried out in nonhuman animal subjects and excised tissue samples. In this study we measured MEI clinically for the first time in human patients who were undergoing off-pump coronary artery bypass (OPCAB) surgery. Our patient population had a 70-100% stenosis of the coronary artery targeted for bypass. We measured MEI continuously during surgery and at 3, 6, 24 and 72hrs postop from two temporary pacing electrodes attached to heart. MEI increased with occlusion of the diseased artery prior to bypass. The percent increase from baseline was correlated to the percent stenosis of the artery. MEI decreased below baseline immediately on reperfusion following bypass and continued decreasing over the measurement period. MEI is a reliable clinical indicator of ischemia and reperfusion in humans.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
EditorsA. Murray
Pages541-543
Number of pages3
Volume29
StatePublished - 2002
Externally publishedYes
EventComputers in Cardiology 2002 - Memphis, TN, United States
Duration: Sep 22 2002Sep 25 2002

Other

OtherComputers in Cardiology 2002
CountryUnited States
CityMemphis, TN
Period9/22/029/25/02

Fingerprint

Acoustic impedance
Electric Impedance
Reperfusion
Ischemia
Coronary Artery Bypass
Surgery
Pathologic Constriction
Arteries
Off-Pump Coronary Artery Bypass
Muscle
Myocardium
Electrodes
Animals
Pumps
Tissue
Population

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Dzwonczyk, R., Del Rio, C., Brown, D. A., Michler, R. E., Wolf, R. K., & Howie, M. B. (2002). Myocardial electrical impedance responds to ischemia and reperfusion in humans. In A. Murray (Ed.), Computers in Cardiology (Vol. 29, pp. 541-543)

Myocardial electrical impedance responds to ischemia and reperfusion in humans. / Dzwonczyk, Roger; Del Rio, C.; Brown, D. A.; Michler, Robert E.; Wolf, R. K.; Howie, M. B.

Computers in Cardiology. ed. / A. Murray. Vol. 29 2002. p. 541-543.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dzwonczyk, R, Del Rio, C, Brown, DA, Michler, RE, Wolf, RK & Howie, MB 2002, Myocardial electrical impedance responds to ischemia and reperfusion in humans. in A Murray (ed.), Computers in Cardiology. vol. 29, pp. 541-543, Computers in Cardiology 2002, Memphis, TN, United States, 9/22/02.
Dzwonczyk R, Del Rio C, Brown DA, Michler RE, Wolf RK, Howie MB. Myocardial electrical impedance responds to ischemia and reperfusion in humans. In Murray A, editor, Computers in Cardiology. Vol. 29. 2002. p. 541-543
Dzwonczyk, Roger ; Del Rio, C. ; Brown, D. A. ; Michler, Robert E. ; Wolf, R. K. ; Howie, M. B. / Myocardial electrical impedance responds to ischemia and reperfusion in humans. Computers in Cardiology. editor / A. Murray. Vol. 29 2002. pp. 541-543
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