TY - JOUR
T1 - Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster
AU - Zeig-Owens, Rachel
AU - Goldfarb, David G.
AU - Luft, Benjamin J.
AU - Yang, Xiaohua
AU - Murata, Kazunori
AU - Ramanathan, Lakshmi
AU - Thoren, Katie
AU - Doddi, Sital
AU - Shah, Urvi A.
AU - Mueller, Alexandra K.
AU - Hall, Charles B.
AU - Giricz, Orsi
AU - Verma, Amit
AU - Prezant, David J.
AU - Landgren, Ola
N1 - Funding Information:
Ola Landgren has received grant support from the National Cancer Institute/National Institutes of Health, Food and Drug Administration, Leukemia and Lymphoma Society (LLS), Rising Tide Foundation, Memorial Sloan Kettering Cancer Center, Multiple Myeloma Research Foundation (MMRF), International Myeloma Foundation (IMF), Paula and Rodger Riney Foundation, Perelman Family Foundation, Amgen, Celgene, Janssen, Takeda, Glen- mark, Seattle Genetics, and Karyopharm; has received honoraria for scientific talks/participated in advisory boards for Adaptive, Amgen, Binding Site, BMS, Celgene, Cellectis, Glenmark, Janssen, Juno, and Pfzer; and served on Independent Data Monitoring Committees for international randomized trials by Takeda, Merck, Janssen, and Theradex. Urvi A. Shah has received support from the following: Honoraria: Janssen, ACCC, MJH Life Sciences. Research funding to the institution: Janssen, Celgene/BMS, Grants: Parker Institute for Cancer Immunotherapy, International Myeloma Society, Paula and Rodger Riney Foundation, Allen Foundation Inc, HealthTree Foundation, Janssen, Celgene/BMS, MSK Paul Calabresi Career Development Award for Clinical Oncology K12CA184746. All other authors declare no competing interests.
Funding Information:
National Institute for Occupational Safety and Health grants (U01 OH011869 and U01 OH011475) and contracts (200-2011-39383, 200-2011-39378, 200-2017-93326, 200-2017-93426 and 200-2017-93432) as well as the Memorial Sloan Kettering Cancer Center Core Grant from the National Cancer Institute (P30 CA008748), the Albert Einstein Cancer Center (P30 CA013330). Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8
Y1 - 2022/8
N2 - An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters. Further investigation was needed to determine if these findings were reproducible in a more heterogeneous WTC-exposed rescue/recovery workers cohort, the Stony Brook University-General Responder Cohort GRC (SBU-GRC). MGUS risk was compared between the cohorts and to published general population estimates from Olmsted County, MN, USA. In this observational seroprevalence study, odds ratios (OR) and age-standardized risk ratios (RR) of MGUS (M-spike and light-chain-MGUS combined), M-spike, and light-chain-MGUS were estimated using logistic regression. Age-standardized prevalences were calculated for white males aged 50–79; RRs were estimated by comparing risk in the WTC-exposed cohort with the Olmsted County screened cohort. SBU-GRC had elevated odds of MGUS compared with FDNY (OR = 1.38; 95%CI = 1.00–1.89). The age-standardized prevalence of MGUS was 9.0/100 persons (95%CI = 7.5–10.6), over two-fold higher than the general population (RR = 2.08; 95%CI = 1.72–2.51); the age-standardized prevalence of light-chain-MGUS was 3.5-fold higher (RR = 3.54; 95%CI = 2.52–4.97). This study adds to mounting evidence supporting an association between WTC/environmental exposures and MGUS among rescue/recovery workers. Access to MGUS screenings for the entire WTC-exposed cohort could allow for treatment interventions that improve survival.
AB - An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters. Further investigation was needed to determine if these findings were reproducible in a more heterogeneous WTC-exposed rescue/recovery workers cohort, the Stony Brook University-General Responder Cohort GRC (SBU-GRC). MGUS risk was compared between the cohorts and to published general population estimates from Olmsted County, MN, USA. In this observational seroprevalence study, odds ratios (OR) and age-standardized risk ratios (RR) of MGUS (M-spike and light-chain-MGUS combined), M-spike, and light-chain-MGUS were estimated using logistic regression. Age-standardized prevalences were calculated for white males aged 50–79; RRs were estimated by comparing risk in the WTC-exposed cohort with the Olmsted County screened cohort. SBU-GRC had elevated odds of MGUS compared with FDNY (OR = 1.38; 95%CI = 1.00–1.89). The age-standardized prevalence of MGUS was 9.0/100 persons (95%CI = 7.5–10.6), over two-fold higher than the general population (RR = 2.08; 95%CI = 1.72–2.51); the age-standardized prevalence of light-chain-MGUS was 3.5-fold higher (RR = 3.54; 95%CI = 2.52–4.97). This study adds to mounting evidence supporting an association between WTC/environmental exposures and MGUS among rescue/recovery workers. Access to MGUS screenings for the entire WTC-exposed cohort could allow for treatment interventions that improve survival.
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U2 - 10.1038/s41408-022-00709-2
DO - 10.1038/s41408-022-00709-2
M3 - Article
C2 - 35995768
AN - SCOPUS:85136215902
SN - 2044-5385
VL - 12
JO - Blood Cancer Journal
JF - Blood Cancer Journal
IS - 8
M1 - 120
ER -