Myeloid-derived suppressor cells: Cellular missiles to target tumors

Dinesh Chandra, Claudia Gravekamp

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

While conventional anticancer therapies, including surgical resection, radiotherapy, and/or chemotherapy, are relatively efficient at eliminating primary tumors, these treatment modalities are largely ineffective against metastases. At least in part, this reflects the rather inefficient delivery of conventional anticancer agents to metastatic lesions. We have recently demonstrated that myeloid-derived suppressor cells (MDSCs) can be used as cellular missiles to selectively deliver a radioisotope-coupled attenuated variant of Listeria monocytogenes to both primary and metastatic neoplastic lesions in mice with pancreatic cancer. This novel immunotherapeutic intervention robustly inhibited tumor growth while promoting a dramatic decrease in the number of metastases.

Original languageEnglish (US)
Article numbere26967
JournalOncoImmunology
Volume2
Issue number11
DOIs
StatePublished - Dec 1 2013

Keywords

  • Cancer vaccine
  • Listeria
  • MDSC
  • Targeted therapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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