Abstract
Background: Sweet’s syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown. Case Report: We present two patients who were diagnosed with SS and concomitant IDH1-mutated MDS. Immunohistochemical staining of their skin lesions showed neutrophils diffusely positive for the IDH1 mutation. Conclusion: These cases demonstrate that IDH1 mutation may be implicated in the pathogenesis of malignancy-associated SS. Future investigation to elucidate this pathway is warranted. Establishing this molecular link can provide an earlier identification of patients with SS who are also at increased risk for developing MDS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2201-2205 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- IDH1 mutation.
- Myelodysplastic syndrome
- Sweet’s syndrome
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Myelodysplastic syndrome and sweet’s syndrome are associated with a mutation in isocitrate dehydrogenase 1. / Snyder, Rose; Libby, Tiffany; Raciti, Patricia; Amin, Bijal D.; Jacobson, Mark; Rakheja, Dinesh; Fleming, Kirsten; Bartenstein, Matthias; Zhu, Changcheng; Goel, Swati; Verma, Amit K.; Shastri, Aditi.
In: Anticancer Research, Vol. 38, No. 4, 01.04.2018, p. 2201-2205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myelodysplastic syndrome and sweet’s syndrome are associated with a mutation in isocitrate dehydrogenase 1
AU - Snyder, Rose
AU - Libby, Tiffany
AU - Raciti, Patricia
AU - Amin, Bijal D.
AU - Jacobson, Mark
AU - Rakheja, Dinesh
AU - Fleming, Kirsten
AU - Bartenstein, Matthias
AU - Zhu, Changcheng
AU - Goel, Swati
AU - Verma, Amit K.
AU - Shastri, Aditi
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: Sweet’s syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown. Case Report: We present two patients who were diagnosed with SS and concomitant IDH1-mutated MDS. Immunohistochemical staining of their skin lesions showed neutrophils diffusely positive for the IDH1 mutation. Conclusion: These cases demonstrate that IDH1 mutation may be implicated in the pathogenesis of malignancy-associated SS. Future investigation to elucidate this pathway is warranted. Establishing this molecular link can provide an earlier identification of patients with SS who are also at increased risk for developing MDS.
AB - Background: Sweet’s syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown. Case Report: We present two patients who were diagnosed with SS and concomitant IDH1-mutated MDS. Immunohistochemical staining of their skin lesions showed neutrophils diffusely positive for the IDH1 mutation. Conclusion: These cases demonstrate that IDH1 mutation may be implicated in the pathogenesis of malignancy-associated SS. Future investigation to elucidate this pathway is warranted. Establishing this molecular link can provide an earlier identification of patients with SS who are also at increased risk for developing MDS.
KW - IDH1 mutation.
KW - Myelodysplastic syndrome
KW - Sweet’s syndrome
UR - http://www.scopus.com/inward/record.url?scp=85045202480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045202480&partnerID=8YFLogxK
U2 - 10.21873/anticanres.12462
DO - 10.21873/anticanres.12462
M3 - Article
C2 - 29599340
AN - SCOPUS:85045202480
VL - 38
SP - 2201
EP - 2205
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4
ER -