Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar, Yuxin Dong, Robert S. Holzman, John Belisle, Irene S. Kourbeti, Tsering Sherpa, Rany Condos, William N. Rom, Suman Laal

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalClinical and Vaccine Immunology
Volume13
Issue number11
DOIs
StatePublished - Nov 2006

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Malate Synthase
Immunodominant Epitopes
Sputum
Viruses
Pulmonary Tuberculosis
Mycobacterium tuberculosis
India
Microscopy
Assays
Microscopic examination
Tuberculosis
HIV
Antibodies
Serum
Mycobacterium tuberculosis antigens

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis. / Achkar, Jacqueline M.; Dong, Yuxin; Holzman, Robert S.; Belisle, John; Kourbeti, Irene S.; Sherpa, Tsering; Condos, Rany; Rom, William N.; Laal, Suman.

In: Clinical and Vaccine Immunology, Vol. 13, No. 11, 11.2006, p. 1291-1293.

Research output: Contribution to journalArticle

Achkar, Jacqueline M. ; Dong, Yuxin ; Holzman, Robert S. ; Belisle, John ; Kourbeti, Irene S. ; Sherpa, Tsering ; Condos, Rany ; Rom, William N. ; Laal, Suman. / Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis. In: Clinical and Vaccine Immunology. 2006 ; Vol. 13, No. 11. pp. 1291-1293.
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