Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar; Yuxin Dong; Robert S. Holzman; John Belisle; Irene S. Kourbeti; Tsering Sherpa; Rany Condos; William N. Rom; Suman Laal

doi:10.1128/CVI.00158-06

Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar, Yuxin Dong, Robert S. Holzman, John Belisle, Irene S. Kourbeti, Tsering Sherpa, Rany Condos, William N. Rom, Suman Laal

Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Original language	English (US)
Pages (from-to)	1291-1293
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1128/CVI.00158-06
State	Published - Nov 2006

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Clinical Biochemistry
Microbiology (medical)

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10.1128/CVI.00158-06

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title = "Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis",

abstract = "The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.",

author = "Achkar, {Jacqueline M.} and Yuxin Dong and Holzman, {Robert S.} and John Belisle and Kourbeti, {Irene S.} and Tsering Sherpa and Rany Condos and Rom, {William N.} and Suman Laal",

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AU - Achkar, Jacqueline M.

AU - Dong, Yuxin

AU - Holzman, Robert S.

AU - Belisle, John

AU - Kourbeti, Irene S.

AU - Sherpa, Tsering

AU - Condos, Rany

AU - Rom, William N.

AU - Laal, Suman

PY - 2006/11

Y1 - 2006/11

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AB - The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

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Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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