Mycobacterium tuberculosis Malate Synthase- And MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Jacqueline M. Achkar, Yuxin Dong, Robert S. Holzman, John Belisle, Irene S. Kourbeti, Tsering Sherpa, Rany Condos, William N. Rom, Suman Laal

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ~80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalClinical and Vaccine Immunology
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 1 2006

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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