Mycobacterium tuberculosis infection in complement receptor 3-deficient mice

C. Hu, T. Mayadas-Norton, Kathryn E. Tanaka, John Chan, P. Salgame

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Complement receptor type 3 (CR3) present on macrophages is used by Mycobacterium tuberculosis as one of its major phagocytic receptors. In this study, we examined the in vivo significance of CR3-mediated phagocytosis on the pathogenesis of disease caused by M. tuberculosis. The outcome of tuberculous infection in mice deficient in the CD11b subunit of CR3 (CR3-/-) on a mixed 129SV and C57BL background and control wild-type counterparts was comparable with respect to survival, bacterial burden, granulomatous lesion development, and cytokine expression in the spleen and lungs. M. tuberculosis infection was also examined in CR3-/- mice on C57BL/6 and BALB/c backgrounds and was found to be similar. In conclusion, our results suggest that in the absence of CR3, M. tuberculosis is able to gain entry into host cells via alternative phagocytic receptors and establish infection. The data also indicate that absence of CR3 does not alter disease course in either the relatively resistant C57BL/6 or the relatively susceptible BALB/c strains of mice.

Original languageEnglish (US)
Pages (from-to)2596-2602
Number of pages7
JournalJournal of Immunology
Volume165
Issue number5
StatePublished - Sep 1 2000
Externally publishedYes

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Macrophage-1 Antigen
Mycobacterium Infections
Mycobacterium tuberculosis
Infection
Inbred C57BL Mouse
Phagocytosis
Spleen
Macrophages
Cytokines
Lung

ASJC Scopus subject areas

  • Immunology

Cite this

Hu, C., Mayadas-Norton, T., Tanaka, K. E., Chan, J., & Salgame, P. (2000). Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. Journal of Immunology, 165(5), 2596-2602.

Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. / Hu, C.; Mayadas-Norton, T.; Tanaka, Kathryn E.; Chan, John; Salgame, P.

In: Journal of Immunology, Vol. 165, No. 5, 01.09.2000, p. 2596-2602.

Research output: Contribution to journalArticle

Hu, C, Mayadas-Norton, T, Tanaka, KE, Chan, J & Salgame, P 2000, 'Mycobacterium tuberculosis infection in complement receptor 3-deficient mice', Journal of Immunology, vol. 165, no. 5, pp. 2596-2602.
Hu C, Mayadas-Norton T, Tanaka KE, Chan J, Salgame P. Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. Journal of Immunology. 2000 Sep 1;165(5):2596-2602.
Hu, C. ; Mayadas-Norton, T. ; Tanaka, Kathryn E. ; Chan, John ; Salgame, P. / Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. In: Journal of Immunology. 2000 ; Vol. 165, No. 5. pp. 2596-2602.
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